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著作: [新田 剛]/[高浜 洋介]/The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins/[Trends in Immunology]

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EID
156009
EOID
876170
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LastModified
2017年11月28日(火) 16:51:06
Operator
大家 隆弘
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高浜 洋介
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 新田 剛
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 高浜 洋介
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins

副題 任意
要約 任意

(英) The life-or-death decision of immune cells makes an essential contribution to immune-system development and the regulation of immune responses. A new family of cell-survival regulators expressed in lymphocytes, termed immune-associated nucleotide-binding proteins (IANs) [also known as GTPase of immunity-associated proteins (GIMAPs)], has been described. The IAN/GIMAP family consists of GTP-binding proteins that share a unique primary structure and whose expression is finely regulated by T-cell receptor signals. Recent studies have shown that IAN/GIMAP family proteins crucially regulate the survival of T cells during development, selection and homeostasis, and are possibly linked to the onset of T-lymphopenia, leukemia and autoimmunity. IAN/GIMAP family proteins might also take part in mitochondrial regulation of lymphocyte apoptosis by interacting with Bcl-2 family proteins.

キーワード 推奨
  1. (英) Animals
  2. (英) Antigens
  3. (英) Cell Survival
  4. (英) GTP-Binding Proteins
  5. (英) Gene Expression Regulation
  6. (英) Humans
  7. (英) Lymphocytes
  8. (英) Receptors, Immunologic
発行所 推奨
誌名 必須 Trends in Immunology(Cell Press)
(pISSN: 1471-4906, eISSN: 1471-4981)
ISSN 任意 1471-4906
ISSN: 1471-4906 (pISSN: 1471-4906, eISSN: 1471-4981)
Title: Trends in immunology
Title(ISO): Trends Immunol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 28
必須 2
必須 58 65
都市 任意
年月日 必須 2007年 0月 初日
URL 任意
DOI 任意 10.1016/j.it.2006.12.002    (→Scopusで検索)
PMID 任意 17196432    (→Scopusで検索)
NAID 任意
WOS 任意 000244374800004
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) Article.PublicationTypeList.PublicationType: Review

  5. (英) NumberOfReferences: 66