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著作: [松本 満]/Transcriptional regulation in thymic epithelial cells for the establishment of self tolerance/[Archivum Immunologiae et Therapiae Experimentalis]

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EID
155659
EOID
710794
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LastModified
2013年9月8日(日) 19:17:06
Operator
大家 隆弘
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松本 満
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種別 必須 総説·解説
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
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学究種別 推奨
組織 推奨
  1. 分子酵素学研究センター(〜2007年3月31日/->組織[疾患酵素学研究センター])
著者 必須
  1. 松本 満([徳島大学.先端酵素学研究所.重点研究部門])
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    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Transcriptional regulation in thymic epithelial cells for the establishment of self tolerance

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要約 任意

(英) Thymic epithelial cells (TECs) play pivotal roles in the establishment of self tolerance through critical dialogue with developing thymocytes. Unique actions of two transcriptional regulators within TECs, NF-kappaB-inducing kinase (NIK) and an autoimmune regulator (AIRE), for the establishment of self tolerance have recently been highlighted by studies using a strain of mouse bearing a natural mutation of the NIK gene (aly mice) and gene-targeted mice, respectively. Previous studies have demonstrated essential roles of NIK downstream of the lymphotoxin-beta receptor (LTbetaR), which is essential for the development of secondary lymphoid organs; aly mice lack all lymph nodes and Peyer's patches because of the defective LTbetaR signaling. Additional roles of NIK in thymic organogenesis downstream of LTPR, mainly through the developmental regulation of TECs, have now emerged, although the corresponding ligand(s) for LTbetaR participating in this action have not been fully characterized. In contrast, AIRE, a gene responsible for the development of an organ-specific autoimmune disease that demonstrates monogenic autosomal recessive inheritance, contributes to the establishment of self tolerance probably by controlling the expression of self antigens through yet undetermined molecular mechanisms. Thus, it is highly likely that a group of genes control self tolerance within TECs through unique and coordinated actions, and that an understanding of this process would help to unravel the pathogenesis of autoimmune disease.

キーワード 推奨
  1. (英) Animals
  2. (英) Epithelial Cells
  3. (英) Gene Expression Regulation
  4. (英) Humans
  5. (英) Self Tolerance
  6. (英) Thymus Gland
  7. (英) Transcription, Genetic
発行所 推奨
誌名 必須 Archivum Immunologiae et Therapiae Experimentalis(Instytut Immunologii i Terapii Doświadczalnej)
(pISSN: 0004-069X, eISSN: 1661-4917)
ISSN 任意 0004-069X
ISSN: 0004-069X (pISSN: 0004-069X, eISSN: 1661-4917)
Title: Archivum immunologiae et therapiae experimentalis
Title(ISO): Arch Immunol Ther Exp (Warsz)
Publisher: Springer Basel
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 55
必須 1
必須 27 34
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年月日 必須 2007年 0月 初日
URL 任意
DOI 任意 10.1007/s00005-007-0007-9    (→Scopusで検索)
PMID 任意 17277892    (→Scopusで検索)
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被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan. mitsuru@ier.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) Article.PublicationTypeList.PublicationType: Review

  5. (英) MedlineDate: 2007 Jan-Feb

  6. (英) NumberOfReferences: 64