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著作: [木戸 博]/[奥村 裕司]/[山田 博司]/[水野 大]/Higashi Youichirou/[矢野 仁康]/Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up-regulating their levels may have therapeutic potential/[Biological Chemistry]

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EID
154911
EOID
876299
Map
0
LastModified
2017年11月28日(火) 17:50:03
Operator
大家 隆弘
Avail
TRUE
Censor
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Owner
木戸 博
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.分子酵素学研究センター(〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター])
著者 必須
  1. 木戸 博([徳島大学.先端酵素学研究所.重点研究部門])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 奥村 裕司
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 山田 博司
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 水野 大
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Higashi Youichirou
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 矢野 仁康
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up-regulating their levels may have therapeutic potential

副題 任意
要約 任意

(英) Influenza A virus (IAV) is one of the most common infectious pathogens in humans. Entry of this virus into cells is primarily determined by host cellular trypsin-type processing proteases, which proteolytically activate viral membrane fusion glycoprotein precursors. Human IAV and murine parainfluenza virus type 1 Sendai virus are exclusively pneumotropic, and the infectious organ tropism of these viruses is determined by the susceptibility of the viral envelope glycoprotein to cleavage by proteases in the airway. Proteases in the upper respiratory tract are suppressed by secretory leukoprotease inhibitor, and those in the lower respiratory tract are suppressed by pulmonary surfactant, which by adsorption inhibits the interaction between the proteases and viral membrane proteins. Although the protease activities are predominant over the activities of inhibitory compounds under normal airway conditions, intranasal administration of inhibitors was able to significantly suppress multi-cycles of viral replication in the airway. In addition, we identified chemical agents that could act as defensive factors by up-regulating the levels of the natural inhibitors and immunoglobulin A (IgA) in airway fluids. One of these compounds, ambroxol, is a mucolytic and anti-oxidant agent that stimulates the release of secretory leukoprotease inhibitor and pulmonary surfactant in the early phase, and IgA in the late phase of infection at an optimal dose, i.e. a dose sufficient to inhibit virus proliferation and increase the survival rate of animals after treatment with a lethal dose of IAV. Another agent, clarithromycin, is a macrolide antibiotic that increases IgA levels through augmentation of interleukin-12 levels and mucosal immunization in the airway. In addition to the sialidase inhibitors, which prevent the release of IAV from infected cells, inhibitors of the processing proteases and chemical agents that augment mucosal immunity and/or levels of the relevant defensive compounds may also ultimately prove to be useful as new anti-influenza agents.

キーワード 推奨
  1. (英) ambroxol
  2. (英) clarithromycin
  3. (英) influenza virus
  4. (英) pulmonary surfactant
  5. (英) secretory leukoprotease inhibitor
  6. (英) LEUKOCYTE-PROTEASE INHIBITOR
  7. (英) SENDAI VIRUS
  8. (英) PROTEINASE-INHIBITOR
  9. (英) TRIGGERS INFECTION
  10. (英) MINI-PLASMIN
  11. 細胞(cells/->キーワード[細胞])
  12. 光局在(light localization)
  13. 浄化(purification)
  14. (英) EMPHYSEMA
  15. (英) ADJUVANT
発行所 推奨
誌名 必須 Biological Chemistry(Gesellschaft für Biochemie und Molekularbiologie)
(pISSN: 1431-6730, eISSN: 1437-4315)
ISSN 任意 1431-6730
ISSN: 1431-6730 (pISSN: 1431-6730, eISSN: 1437-4315)
Title: Biological chemistry
Title(ISO): Biol Chem
Publisher: Walter de Gruyter GmbH
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 385
必須 11
必須 1029 1034
都市 任意
年月日 必須 2004年 4月 7日
URL 任意
DOI 任意 10.1515/BC.2004.133    (→Scopusで検索)
PMID 任意 15576322    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Kuramoto-cho 3-18-15, Tokushima 770-8503, Japan. kido@ier.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) Article.PublicationTypeList.PublicationType: Review

  5. (英) NumberOfReferences: 33