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著作: Katunuma N./[木戸 博]/Biological Functions of Serine Proteases in Mast Cells in Allergic Inflammation/[Journal of Cellular Biochemistry]

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EID
154802
EOID
938156
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0
LastModified
2019年1月28日(月) 17:02:45
Operator
三木 ちひろ
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Owner
木戸 博
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.分子酵素学研究センター(〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター])
著者 必須
  1. (英) Katunuma N.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 木戸 博([徳島大学.先端酵素学研究所.重点研究部門])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Biological Functions of Serine Proteases in Mast Cells in Allergic Inflammation

副題 任意
要約 任意

(英) Serine proteases in mast cell granules, such as chymase, atypical chymase, and tryptase, which are major proteins in the granules, may play important roles in the process of immunoglobulin E (IgE)-mediated degranulation and in pathobiological alterations in tissues. Indeed, inhibitors of chymase, substrate analogs, and antichymase F(ab')2, but not inhibitors of tryptase, markedly inhibited histamine release induced by IgE-receptor bridging but not that induced by Ca ionophore. In contrast, inhibitors of metalloprotease inhibited histamine release induced not only by IgE-receptor bridging but also by Ca ionophore. These results suggest that chymase and metalloprotease are involved at different steps in the process of degranulation. The extents of inhibition of histamine release were closely correlated with the amounts of the inhibitors of chymase accumulated in the granules. After degranulation, the released proteases may in part contribute to pathobiological alterations in allergic disorders through generations of C3a anaphylatoxin and thrombin by human and rat tryptase, respectively, and those of angiotensin II and a chemotactic factor of neutrophils by human and rat chymase, respectively. Moreover, chymase and atypical chymase from rat were shown to destroy type IV collagen, and human tryptase was found to hydrolyze various plasma proteins, such as fibrinogen and high-molecular-weight kininogen. The biological activities of tryptase and chymase from rat may be regulated by their dissociation from and association with trypstatin, an endogenous inhibitor of these proteases.

キーワード 推奨
  1. (英) Animals
  2. (英) Chymases
  3. (英) Histamine Release
  4. (英) Humans
  5. (英) Hypersensitivity
  6. 炎症(inflammation)
  7. (英) Mast Cells
  8. (英) Serine Endopeptidases
発行所 推奨
誌名 必須 Journal of Cellular Biochemistry([Wiley-Liss, Inc.])
(pISSN: 0730-2312, eISSN: 1097-4644)
ISSN 任意 0730-2312
ISSN: 0730-2312 (pISSN: 0730-2312, eISSN: 1097-4644)
Title: Journal of cellular biochemistry
Title(ISO): J Cell Biochem
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 38
必須 4
必須 291 301
都市 任意
年月日 必須 1988年 4月 1日
URL 任意
DOI 任意 10.1002/jcb.240380408    (→Scopusで検索)
PMID 任意 2467915    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-0024273071
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article

  2. (英) Article.PublicationTypeList.PublicationType: Review

  3. (英) NumberOfReferences: 91