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著作: [有澤 孝吉]/[上村 浩一]/[日吉 峰麗]/[武田 英雄]/Saito Hiroshi/Soda Midori/Cadmium-induced renal dysfunction and mortality in two cohorts: diappearance of the association in a generation born later/[Toxicology Letters]

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EID
152450
EOID
724192
Map
0
LastModified
2014年2月19日(水) 14:07:53
Operator
有澤 孝吉
Avail
TRUE
Censor
0
Owner
有澤 孝吉
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 有澤 孝吉
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 上村 浩一
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 日吉 峰麗
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 武田 英雄([徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Saito Hiroshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Soda Midori
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Cadmium-induced renal dysfunction and mortality in two cohorts: diappearance of the association in a generation born later

副題 任意
要約 任意

(英) The association between exposure to environmental cadmium and mortality was investigated in two cohorts. The study population consisted of 275 (cohort I) and 329 (cohort II) residents (aged >or=40 years) in a cadmium-polluted area, Nagasaki Prefecture, Japan, who had participated in health surveys conducted in 1982 and 1992, respectively. The follow-up period extended from 1982 or 1992 to 2005. In the study area, the dietary cadmium intake had decreased after 1980-1983 because of the restoration of cadmium-polluted paddy fields. In cohort I, the mortality rate among those with urinary beta2-microglobulin (beta2-MG) concentration >or=1000 microg/g creatinine (cr.) was 1.41 times higher than the regional reference rate (95% confidence interval [CI] 1.07-1.83). After adjusting for age and other variables, in men, urinary N-acetyl-beta-D-glucosaminidase, and in women, serum creatinine, beta2-MG clearance, and urinary beta2-MG were significantly associated with increased mortality. However, in cohort II, urinary beta2-MG or total protein was not significantly associated with survival. These findings indicate that cadmium-induced renal dysfunction was a significant predictor of mortality, but that such an association is disappearing, probably because of the selective loss of advanced cases and reduced exposure and body burden.

キーワード 推奨
  1. (英) Adult
  2. (英) Aged
  3. (英) Aged, 80 and over
  4. (英) Cadmium
  5. (英) Cohort Studies
  6. (英) Environmental Monitoring
  7. (英) Environmental Pollutants
  8. (英) Female
  9. (英) Health Surveys
  10. (英) Humans
  11. (英) Japan
  12. (英) Kaplan-Meier Estimate
  13. (英) Kidney Diseases
  14. (英) Male
  15. (英) Middle Aged
  16. (英) Proportional Hazards Models
  17. (英) Time Factors
発行所 推奨
誌名 必須 Toxicology Letters([Elsevier])
(pISSN: 0378-4274, eISSN: 1879-3169)
ISSN 任意 0378-4274
ISSN: 0378-4274 (pISSN: 0378-4274, eISSN: 1879-3169)
Title: Toxicology letters
Title(ISO): Toxicol Lett
Publisher: Elsevier Ireland Ltd
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 169
必須 3
必須 214 221
都市 任意
年月日 必須 2007年 6月 初日
URL 任意
DOI 任意 10.1016/j.toxlet.2007.01.009    (→Scopusで検索)
PMID 任意 17336471    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意 11
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Tokushima 770-8503, Japan. arisawa@basic.med.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't