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著作: [伊東 進]/Kubo Kenichirou/[本田 浩仁]/Sannomiya Katsutaka/Aying Yuan/Mei Wei/Mi Shen/[清水 一郎]/Ii Kunio/Histochemical and immunohistochemical investigation of guanase and/[The Journal of Medical Investigation : JMI]

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EID
147900
EOID
878484
Map
0
LastModified
2017年12月4日(月) 14:08:00
Operator
[ADMIN]
Avail
TRUE
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Owner
[学科長]/[徳島大学.医学部.医学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 伊東 進
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kubo Kenichirou
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 本田 浩仁
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Sannomiya Katsutaka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Aying Yuan
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Mei Wei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Mi Shen
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 清水 一郎
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Ii Kunio
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Histochemical and immunohistochemical investigation of guanase and

副題 任意
要約 任意

(英) Guanase is known as an enzyme released from the liver. Recently, cloning and sequencing of the guanase gene were reported. In addition, almost simultaneously, it was reported that an unknown protein that binds to neuronal and endocrine lethal(1)-discs large (NE-dlg), one of the membrane-associated guanylate kinase homologues (MAGUK) family proteins involved in synaptic connection between neurons, was cloned and named nedasin (NE-dlg associated protein), whose sequence was almost identical to that of guanase. We immunostained fresh frozen sections of surgically removed human liver, kidney, and small intestine with anti-nedasin antibody, and simultaneously performed histochemical staining for guanase for comparison. Histochemically, guanase activity was observed in the cytoplasm of hepatocytes and biliary epithelium on the liver, in the mucosal epithelium on the small intestine, and in the proximal tubule on the kidney. Immunohistochemically, a brown discoloration due to DAB oxidation was seen in the cytoplasm of hepatocytes and biliary epithelium on the liver, in the proximal tubule but in the distal tubule a little on the kidney, in the mucosal epithelium on the small intestine. The stained region of the liver and the small intestine were different from that of the kidney. The different staining properties dependent on the organs were considered to be due to different isozymes. The physiological significance of guanase may vary with the isozymes, further studies are considered necessary.

キーワード 推奨
  1. (英) Aminohydrolases
  2. (英) Guanine Deaminase
  3. (英) Histocytochemistry
  4. (英) Humans
  5. (英) Immunohistochemistry
  6. (英) Intestine, Small
  7. (英) Isoenzymes
  8. (英) Kidney
  9. (英) Liver
  10. (英) Muscle, Skeletal
発行所 推奨
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 53
必須 3.4
必須 264 270
都市 任意
年月日 必須 2006年 8月 初日
URL 任意
DOI 任意 10.2152/jmi.53.264    (→Scopusで検索)
PMID 任意 16953063    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
機関リポジトリ 110821
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School.

  2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article