146696: Kano Mihoko/Kitano Takako/Ikemoto Madoka/[平坂勝也]/Asanoma Yuki/Ogawa Takayuki/Takeda Shinichi/Nonaka Ikuya/Adams R. Gregory/Baldwin M. Kenneth/Oarada Motoko/[岸恭一]/[二川健]/Isolation and characterization of a novel gene sfig in rat skeletal muscle up-regulated by spaceflight (STS-90)/[The Journal of Medical Investigation : JMI]

著作: Kano Mihoko/Kitano Takako/Ikemoto Madoka/[平坂勝也]/Asanoma Yuki/Ogawa Takayuki/Takeda Shinichi/Nonaka Ikuya/Adams R. Gregory/Baldwin M. Kenneth/Oarada Motoko/[岸恭一]/[二川健]/Isolation and characterization of a novel gene sfig in rat skeletal muscle up-regulated by spaceflight (STS-90)/[The Journal of Medical Investigation : JMI]

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EID: 146696
EOID: 878378
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LastModified: 2017年12月4日(月) 14:06:56
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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カテゴリ

推奨

共著種別

推奨

学究種別

推奨

組織

推奨

著者

必須

(英) Kano Mihoko

役割任意

貢献度任意

学籍番号推奨
(英) Kitano Takako

役割任意

貢献度任意

学籍番号推奨
(英) Ikemoto Madoka

役割任意

貢献度任意

学籍番号推奨
平坂勝也

役割任意

貢献度任意

学籍番号推奨
(英) Asanoma Yuki

役割任意

貢献度任意

学籍番号推奨
(英) Ogawa Takayuki

役割任意

貢献度任意

学籍番号推奨
(英) Takeda Shinichi

役割任意

貢献度任意

学籍番号推奨
(英) Nonaka Ikuya

役割任意

貢献度任意

学籍番号推奨
(英) Adams R. Gregory

役割任意

貢献度任意

学籍番号推奨
(英) Baldwin M. Kenneth

役割任意

貢献度任意

学籍番号推奨
(英) Oarada Motoko

役割任意

貢献度任意

学籍番号推奨
岸恭一

役割任意

貢献度任意

学籍番号推奨
二川健([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])

役割任意

貢献度任意

学籍番号推奨

題名

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(英) Isolation and characterization of a novel gene sfig in rat skeletal muscle up-regulated by spaceflight (STS-90)

副題

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要約

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(英) We obtained the skeletal muscle of rats exposed to weightless conditions during a 16-day-spaceflight (STS-90). By using a differential display technique, we identified 6 up-regulated and 3 down-regulated genes in the gastrocnemius muscle of the spaceflight rats, as compared to the ground control. The up-regulated genes included those coding Casitas B-lineage lymphoma-b, insulin growth factor binding protein-1, titin and mitochondrial gene 16 S rRNA and two novel genes (function unknown). The down-regulated genes included those encoding RNA polymerase II elongation factor-like protein, NADH dehydrogenase and one novel gene (function unknown). In the present study, we isolated and characterized one of two novel muscle genes that were remarkably up-regulated by spaceflight. The deduced amino acid sequence of the spaceflight-induced gene (sfig) comprises 86 amino acid residues and is well conserved from Drosophila to Homo sapiens. A putative leucine-zipper structure located at the N-terminal region of sfig suggests that this gene may encode a transcription factor. The up-regulated expression of this gene, confirmed by Northern blot analysis, was observed not only in the muscles of spaceflight rats but also in the muscles of tail-suspended rats, especially in the early stage of tail-suspension when gastrocnemius muscle atrophy initiated. The gene was predominantly expressed in the kidney, liver, small intestine and heart. When rat myoblastic L6 cells were grown to 100% confluence in the cell culture system, the expression of sfig was detected regardless of the cell differentiation state. These results suggest that spaceflight has many genetic effects on rat skeletal muscle.

キーワード

推奨

(英) Amino Acid Sequence
(英) Animals
(英) Base Sequence
(英) Cell Line
(英) DNA, Complementary
(英) Gene Expression Profiling
(英) Gene Expression Regulation
(英) Immobilization
(英) Leucine Zippers
(英) Male
(英) Molecular Sequence Data
(英) Muscle Proteins
(英) Muscle, Skeletal
(英) Organ Specificity
(英) Rats
(英) Rats, Wistar
(英) Sequence Homology, Amino Acid
(英) Space Flight
(英) Species Specificity
(英) Subtraction Technique
(英) Tail
(英) Transcription Factors

発行所

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誌名

必須

The Journal of Medical Investigation : JMI([徳島大学.医学部])

(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN	任意	1343-1420 ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMI Title(ISO): J Med Invest Supplier: 徳島大学 Publisher: University of Tokushima (NLM Catalog) (Webcat Plus) (医中誌Web) (J-STAGE) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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1-2

頁

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39 47

都市

任意

年月日

必須

2003年 2月初日

URL

任意

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12630567&itool=iconabstr&query_hl=1&itool=pubmed_docsum

DOI

任意

PMID

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12630567 (→Scopusで検索)

CRID

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WOS

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Scopus

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2-s2.0-0037762735

機関リポジトリ

110676

評価値

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被引用数

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指導教員

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備考

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(英) Article.Affiliation: Department of Nutrition, The University of Tokushima School of Medicine, Tokushima, Japan.
(英) Article.PublicationTypeList.PublicationType: Comparative Study
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't
(英) KeywordList.Keyword: NASA Discipline Musculoskeletal
(英) KeywordList.Keyword: NASA Experiment Number 9301103
(英) KeywordList.Keyword: Non-NASA Center
(英) SpaceFlightMission: Flight Experiment
(英) SpaceFlightMission: STS-90 Shuttle Project
(英) SpaceFlightMission: manned
(英) SpaceFlightMission: short duration

徳島大学教育・研究者情報データベース(EDB)

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