徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: [東 博之]/動脈硬化と高脂血症/[四国医学雑誌]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
146076
EOID
877243
Map
0
LastModified
2017年12月4日(月) 13:55:28
Operator
[ADMIN]
Avail
TRUE
Censor
0
Owner
[研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
Read
継承
Write
継承
Delete
継承
種別 必須 総説·解説
言語 必須
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 東 博之
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Atherosclerosis and hyperlipidemia

(日) 動脈硬化と高脂血症

副題 任意
要約 任意

(日) It is well known that four major risk factors for atherosclerosis include diabetes mellitus,hypertension, hyperlipidemia and smoking. Among these risk factors, management ofhyperlipidemia, especially hyper-LDL cholesterolemia, has become to be strictly achieved by theappearance of statins. Many randomized control trials using statins have been performed, andthe effectiveness in reduction of cardiovascular events is clearly established. Under thesecircumstances, we planed and performed the Shikoku Hyperlipidemia Study(SHS)to revealhow do we treat and what degree do we strictly manage patients with hyperlipidemia.Evidence obtained by The SHS study were 1)unmeasurement rates of serum cholesterollevels in categories B and C were 28.1% and 18.2%, respectively, 2)among patients incategories B and C who need to be treated by drugs, only 35.5% and 35.9% of patients incategories B and C were treated, respectively, 3)drugs medicated in such patients weremostly statins and a single kind of statin was administered, and 4)rate of successfullytreated patients in category B was 40∼50% and that in category C was 20∼30%. Whenthis analysis, which was performed based upon guideline published in 1997, was re-analyzedby new guideline published in 2002, rates of successfully treated patients in categories A, B1,B2, B3, B4, and C were 91.7%, 66.1%, 77.6%, 42.9%, 60.7%, and 32.6%, respectively.Pleiotropic effects of statins have been postulated, however, a couple of issues are stillelusive ; that is, 1)can statins suppress the progression of atherosclerosis by the mechanismother than cholesterol lowering in humans? and 2)should statins be administered to patientsfor secondary and primary preventions against cardiovascular events to anticipate pleiotropiceffects of statins?. Evidence obtained so far suggest that statins exert its pleiotropic effectsvia 1)enhancement of NO production by phosphorylation of eNOS, Akt and PI 3 kinase, 2)inhibition of Ras activation by reduction of farnesyl-pyrophosphate, and 3)inhibition of Rhofamily activation by reduction of geranylgeranyl-pyrophosphate, and that Heart ProtectionStudy and ASCOT-LLA study revealed that additive benefits can be elicited whenhyperlipidemic patients bearing many risk factors including diabetes mellitus were treatedwith statins.In conclusion, we need to treat patients with hyperlipidemia in consideration of thequality and quantity of risk factors for cardiovascular diseases.

キーワード 推奨
  1. (英) atherosclerosis
  2. (英) hyperlipidemia
  3. (英) stain
  4. (英) risk factors
  5. (英) pleiotropic effect
発行所 推奨 (日) 徳島医学会
誌名 必須 四国医学雑誌([徳島医学会])
(pISSN: 0037-3699)
ISSN 任意 0037-3699
ISSN: 0037-3699 (pISSN: 0037-3699)
Title: 四国医学雑誌
Supplier: 徳島大学
Publisher: Tokushima Igakkai
 (Webcat Plus  (医中誌Web  (Scopus (Scopus information is found. [need login])
必須 60
必須 3,4
必須 69 74
都市 任意 徳島(Tokushima/[日本国])
年月日 必須 2004年 8月 25日
URL 任意 http://ci.nii.ac.jp/naid/40006663371/
DOI 任意
PMID 任意
NAID 任意 40006663371
WOS 任意
Scopus 任意
機関リポジトリ 42517
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意