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著作: Ogino Tomoe/Zhu Min/Murakami Takashi/[桒島 正道]/Shima Kenji/Effect of partial pancreatectomy on β-cell mass in the remnant pancreas of Wistar fatty rats/[The Journal of Medical Investigation : JMI]

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EID
145790
EOID
907332
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2018年5月23日(水) 17:08:56
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Ogino Tomoe
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Zhu Min
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Murakami Takashi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 桒島 正道
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Shima Kenji
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Effect of partial pancreatectomy on β-cell mass in the remnant pancreas of Wistar fatty rats

副題 任意
要約 任意

(英) Wistar fatty rat, which has been established by transferring the fa gene of Zucker fatty rat to the Wistar Kyoto rat, has many features in common with human NIDDM. It exhibits hyperglycemic obesity with hyperinsulinemia and insulin resistance. It is unclear, however, whether a defect in the beta-cell proliferation is related to the onset of diabetes mellitus together with insulin resistance in this model rat. To determine this, we compared non-fasting plasma glucose levels, insulin content and beta-cell mass in the remnant pancreas of Wistar fatty rats with those in their diabetic-resistant lean counterparts after a 70% partial pancreatectomy. We also examined whether such a defect, if present, could be improved by either phlorizin or nicotinamide. We further investigated if there were any differences in these parameters between the phenotypically identical but genotypically different Wistar lean rats with a gene type of homogeneous Fa/Fa and that of heterogeneous Fa/fa. Male rats, 6 weeks of age, were allocated at random into two groups: 70% pancreatectomy (Px) and sham-pancreatectomy (sham). A sustained hyperglycemia was evident in the Px Wistar fatty rats after surgery, which was accompanied by a reduction of insulin content and beta-cell mass in the remnant pancreas. The changes in insulin content and beta-cell mass were unaffected by restoration of normoglycemia, induced by phlorizin injection. The administration of nicotinamide partially ameliorated the sustained hyperglycemia by a slight but not significant increase in beta-cell mass. No discernible difference in the above parameters was observed between the Wistar lean rats with Fa/Fa and those with Fa/fa. These findings suggest that Wistar fatty rats have a poor capacity for proliferation of pancreatic beta-cells, which causes the onset of overt diabetes along with insulin resistance due to extreme obesity.

キーワード 推奨
  1. (英) Animals
  2. (英) Blood Glucose
  3. (英) Cell Division
  4. (英) Diabetes Mellitus
  5. (英) Diabetes Mellitus, Type 2
  6. (英) Disease Models, Animal
  7. (英) Genotype
  8. (英) Hyperglycemia
  9. (英) Insulin
  10. (英) Insulin Resistance
  11. (英) Islets of Langerhans
  12. (英) Male
  13. (英) Niacinamide
  14. (英) Obesity
  15. (英) Pancreatectomy
  16. (英) Phenotype
  17. (英) Phlorhizin
  18. (英) Rats
  19. (英) Rats, Inbred WKY
  20. (英) Rats, Mutant Strains
  21. (英) Rats, Wistar
  22. (英) Rats, Zucker
発行所 推奨
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 45
必須 1-4
必須 103 110
都市 任意
年月日 必須 1998年 8月 初日
URL 任意
DOI 任意
PMID 任意 9864970    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
機関リポジトリ 111630
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Comparative Study

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't