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著作: Tokudome T/Horio T/[添木 武]/Mori K/Kishimoto I/Suga S/Yoshihara F/Kawano Y/Kohno M/Kangawa K/Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways./[Endocrinology]

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EID
142014
EOID
686103
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0
LastModified
2013年5月2日(木) 19:22:33
Operator
大家 隆弘
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TRUE
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Owner
添木 武
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Tokudome T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Horio T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 添木 武([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Mori K
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kishimoto I
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Suga S
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Yoshihara F
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Kawano Y
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Kohno M
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. (英) Kangawa K
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways.

副題 任意
要約 任意

(英) C-type natriuretic peptide (CNP) is known to play a role in the local regulation of vascular tone. We recently found that CNP is also produced by cardiac ventricular cells. However, its local effect on myocyte hypertrophy remains to be elucidated. The present study investigated the effects of CNP on cultured cardiac myocyte hypertrophy and the interaction between CNP and endothelin-1 (ET-1) signaling pathways. CNP attenuated basal and ET-1-augumented protein synthesis, atrial natriuretic peptide secretion, hypertrophy-related gene expression, GATA-4 and MEF-2 DNA binding activities, Ca(2+)/calmodulin-dependent kinase II activity, and ERK phosphorylation. CNP also inhibited ET-1-induced increase in intracellular Ca(2+) concentration. These effects of CNP were mimicked by a cGMP analog, 8-bromo cGMP. However, the inhibitory effects of CNP on the hypertrophic response of myocytes were significantly diminished at high concentrations of ET-1. Although CNP increased intracellular cGMP levels in myocytes, ET-1 suppressed CNP-induced cellular cGMP accumulation. A protein kinase C activator and Ca(2+) ionophore mimicked this suppressive effect of ET-1. We further examined the effect of CNP on the paracrine action of ET-1 secreted from cardiac nonmyocytes. CNP and 8-bromo cGMP significantly inhibited ET-1 secretion from nonmyocytes. Although nonmyocyte-conditioned medium increased the protein synthesis in myocytes through endogenous ET-1 action, this increase was significantly attenuated by pretreatment of nonmyocytes with CNP and 8-bromo cGMP. These findings demonstrate that CNP inhibits ET-1-induced cardiac myocyte hypertrophy via a cGMP-dependent mechanism, and conversely, ET-1 inhibits CNP signaling by a protein kinase C- and Ca(2+)-dependent mechanism, suggesting mutual interference between CNP and ET-1 signaling pathways.

キーワード 推奨
  1. (英) Animals
  2. (英) Calcium
  3. (英) Calcium-Calmodulin-Dependent Protein Kinase Type 2
  4. (英) Calcium-Calmodulin-Dependent Protein Kinases
  5. (英) Cardiomegaly
  6. (英) Cells, Cultured
  7. (英) Cyclic GMP
  8. (英) DNA
  9. (英) DNA-Binding Proteins
  10. (英) Drug Interactions
  11. (英) Endothelin-1
  12. (英) GATA4 Transcription Factor
  13. (英) Mitogen-Activated Protein Kinases
  14. (英) Myocardium
  15. (英) Myogenic Regulatory Factors
  16. (英) Natriuretic Peptide, C-Type
  17. (英) Phosphorylation
  18. (英) Rats
  19. (英) Rats, Wistar
  20. (英) Signal Transduction
  21. (英) Transcription Factors
発行所 推奨
誌名 必須 Endocrinology([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)
ISSN 任意 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 145
必須 5
必須 2131 2140
都市 任意
年月日 必須 2004年 1月 28日
URL 任意
DOI 任意 10.1210/en.2003-1260    (→Scopusで検索)
PMID 任意 14749356    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Research Institute, National Cardiovascular Center, Suita, Osaka 565-8565, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't