徳島大学 教育・研究者情報データベース(EDB)

1. 安友 康二([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])

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2. 前田 健一

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3. (英) Nagata Shigekazu

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4. (英) Nagasawa Hideyuki

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5. (英) Okada Kaname

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6. (英) Good Robert A.

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7. 黒田 𣳾弘

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8. (英) Himeno Kunisuke

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(英) Defective T cells from gld mice play a pivotal role in development of Thy-1.2+B220+ cells and autoimmunity

(英) The gld mouse represents a fascinating animal model of autoimmune disease, which is characterized by massive development of Thy-1.2+B220+ CD4-CD8- cells. These cells thus have double positive markers for T and B cells, but are double negative for CD4 and CD8 markers and are thus designated DN cells in the present context. An additional important feature in gld mice is a defect in expression of Fas ligand. To investigate the regulatory role of bone marrow-derived cells for the development of these DN cells and of gld autoimmunity, we constructed chimeric mice transplanted with fetal liver cells or fetal thymus from gld mice into nonirradiated severe combined immunodeficient (SCID) mice. These chimeric mice regenerated, developed both these DN cells and the gld autoimmune syndrome and also generalized lymphoproliferative disorders. However, when fetal liver cells from both gld and non-gld mice (C57BL/10 Thy-1.1 mice) were co-transplanted into SCID mice, the development of DN cells was apparently inhibited. Further, this inhibition was also seen in SCID mice that had been grafted with both gld and non-gld fetal thymus revealing the pivotal role played by T cells in development of DN cells. When B cells purified from non-gld (C3H+/+) mice were transplanted into SCID mice grafted with gld fetal thymus, the development of DN cells was not inhibited. Taken together, these findings indicate that T cells from non-gld mice inhibit the expression of gld features, e.g., lymphoproliferation, immune-based nephritic disease, and autoantibody production. These findings also suggest that the Fas ligand is selectively expressed on T cells.

1. (英) Animals
2. (英) Antigens, Surface
3. (英) Autoimmune Diseases
4. (英) B-Lymphocytes
5. (英) Enzyme-Linked Immunosorbent Assay
6. (英) Fetal Tissue Transplantation
7. (英) Flow Cytometry
8. (英) Leukocyte Common Antigens
9. (英) Liver Transplantation
10. (英) Lymphocyte Activation
11. (英) Lymphocyte Culture Test, Mixed
12. (英) Mice
13. (英) Mice, Inbred C3H
14. (英) Mice, Inbred C57BL
15. (英) Mice, Mutant Strains
16. (英) Mice, SCID
17. Tリンパ球(T lymphocytes)
18. (英) Thy-1 Antigens
19. (英) Thymus Gland
20. (英) Transplantation Chimera
21. (英) fas Receptor

1. (英) Article.PublicationTypeList.PublicationType: Journal Article

2. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

3. (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.