徳島大学 教育・研究者情報データベース(EDB)

1. (英) Chowdhury Mohammed Golam Mowla

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2. (英) Furukawa Atsuko

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3. 香川 征

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4. 前田 健一

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5. 安友 康二([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])

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6. (英) Himeno Kunisuke

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(英) B cells are required as APC for antigen-specific T cell proliferation but not the differentiation or priming of those T cells

(英) We studied the influences of B cells on functional differentiation of T cells using SCID mice grafted with fetal thymus of C.B-17 mice (TG mice). T cells were shown to be reconstituted in TG mice without B cell development. These mice showed normal DTH response to SRBC and OVA. LN cells of these mice produced cytokines including IL-2, IL-4, IL-6 and IFN-gamma according to Con A stimulation. Thus, majority of T cell functions seem to differentiate in the absence of B cells. However, T cells of TG mice failed to proliferate in response to immunizing antigens in vitro, although they responded well to stimulation with Con A. This unresponsiveness of T cells in TG mice to these antigens was restored when antigen-primed B cells were added to the proliferation assay. Such an inability of T cells in antigen-specific proliferation was not seen in SCID mice grafted with C.B-17 fetal liver cells, in which B cells as well as T cells were efficiently reconstituted (FLT mice). T cell proliferation to immunizing antigen was also abrogated in FLT mice when B cells were depleted from lymphoid population. These results indicate that T cells can functionally differentiate and be primed in the absence of B cells, but they require B cells to proliferate in response to foreign antigens.

1. (英) Animals
2. (英) Antigen-Presenting Cells
3. (英) B-Lymphocytes
4. 細胞分化(cell differentiation)
5. 細胞分裂(cell division)
6. (英) Concanavalin A
7. (英) Epitopes
8. (英) Immunization
9. (英) Lymphocyte Activation
10. (英) Mice
11. (英) Mice, SCID
12. Tリンパ球(T lymphocytes)
13. (英) Thymus Gland

1. (英) Article.PublicationTypeList.PublicationType: Journal Article