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著作: [北村 修]/Wee Sunmee/Spacio E Sheila/Koob F George/Pulvirenti Luigi/Escalation of methamphetamine self-administration in rats: a dose effect function/[Psychopharmacology]

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2012年10月29日(月) 13:59:39
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. The Scripps Research Institute
著者 必須
  1. 北村 修
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Wee Sunmee
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Spacio E Sheila
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Koob F George
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Pulvirenti Luigi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Escalation of methamphetamine self-administration in rats: a dose effect function

副題 任意
要約 任意

(英) The transition from stable to escalated drug intake has been demonstrated in rats self-administrating cocaine and heroin using a single dose of drug. To investigate the prolonged exposure to methamphetamine self-administration and the effect of various training doses of methamphetamine on the changes of methamphetamine intake over a 21-day period. Two groups of rats were trained in 1-h daily sessions of methamphetamine self-administration [0.033 mg/infusion (inf); approximately 0.066 mg/kg/inf]. Methamphetamine access was increased to 6 h in one group [Long Access (LgA)] or maintained at 1 h in another [Short Access (ShA)]. The same procedure was repeated in rats exposed to different training doses of methamphetamine (0.05, 0.1, and 0.2 mg/kg/inf). In LgA rats, total and first hour intake of methamphetamine significantly increased compared to ShA rats at various methamphetamine doses. LgA animals, at all doses in the second study, escalated intake to 8-9 mg/kg per 6-h session, with the most rapid escalation occurring at 3-5 days at a methamphetamine dose of 0.1 mg/kg/inf. The escalation of drug intake observed with extended access is produced at multiple doses of methamphetamine. The rapidity of escalation depends on the dose. Ultimately, all doses in the dose-response study engendered self-administration of the same amount of total drug in a 6-h session in the extended-access group. Results suggest that the rapidity of escalation is dependent on dose and has an upper limit of intake over a period of 21 days.

キーワード 推奨
  1. (英) Animals
  2. (英) Behavior, Addictive
  3. (英) Conditioning, Operant
  4. (英) Dose-Response Relationship, Drug
  5. (英) Male
  6. (英) Methamphetamine
  7. (英) Rats
  8. (英) Rats, Wistar
  9. (英) Self Administration
発行所 推奨 (英) Springer Berlin
誌名 必須 Psychopharmacology([Springer-Verlag])
(pISSN: 0033-3158, eISSN: 1432-2072)
ISSN 任意 0033-3158
ISSN: 0033-3158 (pISSN: 0033-3158, eISSN: 1432-2072)
Title: Psychopharmacology
Title(ISO): Psychopharmacology (Berl)
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 186
必須 1
必須 48 53
都市 任意 (英) Heidelberg
年月日 必須 2006年 5月 初日
URL 任意
DOI 任意 10.1007/s00213-006-0353-z    (→Scopusで検索)
PMID 任意 16552556    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Molecular and Integrative Neurosciences Department, SP30-2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural