著作: Yoshizaki Chihiro/Tsukane Mariko/[山内 卓]/Overexpression of tau leads to the stimulation of neurite outgrowth, the activation of caspase 3 activity, and accumulation and phosphorylation of tau in neuroblastoma cells on cAMP treatment/[Neuroscience Research]
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| 種別 | 必須 | 学術論文(審査論文) | |||||||||||||||||||||||||||
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| 言語 | 必須 | 英語 | |||||||||||||||||||||||||||
| 招待 | 推奨 | ||||||||||||||||||||||||||||
| 審査 | 推奨 | ||||||||||||||||||||||||||||
| カテゴリ | 推奨 | ||||||||||||||||||||||||||||
| 共著種別 | 推奨 | ||||||||||||||||||||||||||||
| 学究種別 | 推奨 | ||||||||||||||||||||||||||||
| 組織 | 推奨 | ||||||||||||||||||||||||||||
| 著者 | 必須 |
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| 題名 | 必須 |
(英) Overexpression of tau leads to the stimulation of neurite outgrowth, the activation of caspase 3 activity, and accumulation and phosphorylation of tau in neuroblastoma cells on cAMP treatment |
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| 副題 | 任意 | ||||||||||||||||||||||||||||
| 要約 | 任意 |
(英) To explore changes to the tau molecule in Alzheimer's disease, we studied the effect of tau expression in stably transfected neuroblastoma x glioma hybrid NG108-15 cells (tau cells). Tau cells had a similar shape to, but more neurites than, wild type NG108-15 cells (wild type cells). When treated with cAMP, tau cells began to form neurites within 2h. After that, these neurites became longer and thicker than those of wild type cells. An accumulation and increased phosphorylation of tau were observed after 8 h and caspase 3 activity was increased after 4 h in tau cells, but not in wild type cells, upon treatment with cAMP. Caspase 3 activity was activated after the initiation of morphological change, and before the accumulation of tau in tau cells. Under these conditions, apoptotic cell death was not observed and tau was colocalized with tubulin. However, the accumulated tau molecules did not associate with tubulin and were dislocated around and in the nuclei of tau cells. These observations have implications for the cellular causes of Alzheimer's disease where the accumulation and mislocation of tau occur concomitant with neuronal degeneration. |
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| キーワード | 推奨 |
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| 発行所 | 推奨 | 日本神経科学学会 | |||||||||||||||||||||||||||
| 誌名 | 必須 |
Neuroscience Research([日本神経科学学会])
(pISSN: 0168-0102, eISSN: 1872-8111)
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| 巻 | 必須 | 49 | |||||||||||||||||||||||||||
| 号 | 必須 | 4 | |||||||||||||||||||||||||||
| 頁 | 必須 | 363 371 | |||||||||||||||||||||||||||
| 都市 | 任意 | ||||||||||||||||||||||||||||
| 年月日 | 必須 | 2004年 8月 1日 | |||||||||||||||||||||||||||
| URL | 任意 | http://dx.doi.org/10.1016/j.neures.2004.04.005 | |||||||||||||||||||||||||||
| DOI | 任意 | 10.1016/j.neures.2004.04.005 (→Scopusで検索) | |||||||||||||||||||||||||||
| PMID | 任意 | 15236861 (→Scopusで検索) | |||||||||||||||||||||||||||
| CRID | 任意 | 1571135650559063808 | |||||||||||||||||||||||||||
| NAID | 10023900272 | ||||||||||||||||||||||||||||
| WOS | 任意 | 000222883300002 | |||||||||||||||||||||||||||
| Scopus | 任意 | ||||||||||||||||||||||||||||
| 評価値 | 任意 | ||||||||||||||||||||||||||||
| 被引用数 | 任意 | ||||||||||||||||||||||||||||
| 指導教員 | 推奨 | ||||||||||||||||||||||||||||
| 備考 | 任意 |
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