著作: Alizadeh, Mohammad/[太田 房雄]/[細井 和雄]/Kato, Makoto/Sakai, Tohru/Satter, A., Mohammed/Altered allergic cytokine and antibody response in mice treated with Bisphenol A/[The Journal of Medical Investigation : JMI]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | Peer Review | |||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 |
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著者 | 必須 | ||||
題名 | 必須 |
(英) Altered allergic cytokine and antibody response in mice treated with Bisphenol A |
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副題 | 任意 | ||||
要約 | 任意 |
(英) The objective of this study was to elucidate if Bisphenol A (BPA) administration modulates T helper (Th) cell component of immune responses in a mouse challenged with ovalbumin (OVA), a major food antigen. BALB/c mice, (6 weeks old, female) were orally given either OVA (OVA-fed) or water (Water-fed), immunized intraperitoneally with OVA and injected with either BPA in corn oil or the vehicle alone. After subsequent 2nd immunization, serum titers of total IgE, OVA-specific IgE, IgG, IgG1 IgG2a and ability of their splenocytes for production of interferon (IFN) -gamma, interleukin (IL) -4 and IL-12 were examined by ELISA. Lymphocyte proliferation assay against concanavalin A (Con A) or OVA was also performed for 3H-Thymidine incorporation. In Water-fed groups, treatment with BPA resulted in lower titers of total IgE (P<0.01) and higher levels IgG2a (P<0.05) followed by a higher IFN-gamma (P<0.05) and IL-12 (P<0.05) with an intact IL-4. When OVA-fed groups were examined, the compound did not change production of total and OVA-specific IgE and -IgG2a but resulted in lower production of IFN-gamma (P<0.05). Also, BPA resulted in impaired lymphocyte proliferation to Con A in Water-fed groups (P<0.05) but not in tolerated animals. The findings indicate that BPA results in augmentation of Th1 immune responses but no significant effect on an established tolerance to OVA. |
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キーワード | 推奨 |
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発行所 | 推奨 | ||||
誌名 | 必須 |
The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
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巻 | 必須 | 53 | |||
号 | 必須 | 1, 2 | |||
頁 | 必須 | 70 80 | |||
都市 | 任意 | 徳島(Tokushima/[日本国]) | |||
年月日 | 必須 | 2006年 2月 初日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.2152/jmi.53.70 (→Scopusで検索) | |||
PMID | 任意 | 16537998 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | ||||
機関リポジトリ | 110790 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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