徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.栄養医科学講座(2004年4月1日〜)
2. 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座(2004年4月1日〜2015年3月31日)

1. (英) Alizadeh, Mohammad

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2. 太田 房雄

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3. 細井 和雄

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4. (英) Kato, Makoto

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5. (英) Sakai, Tohru

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6. (英) Satter, A., Mohammed

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(英) Altered allergic cytokine and antibody response in mice treated with Bisphenol A

(英) The objective of this study was to elucidate if Bisphenol A (BPA) administration modulates T helper (Th) cell component of immune responses in a mouse challenged with ovalbumin (OVA), a major food antigen. BALB/c mice, (6 weeks old, female) were orally given either OVA (OVA-fed) or water (Water-fed), immunized intraperitoneally with OVA and injected with either BPA in corn oil or the vehicle alone. After subsequent 2nd immunization, serum titers of total IgE, OVA-specific IgE, IgG, IgG1 IgG2a and ability of their splenocytes for production of interferon (IFN) -gamma, interleukin (IL) -4 and IL-12 were examined by ELISA. Lymphocyte proliferation assay against concanavalin A (Con A) or OVA was also performed for 3H-Thymidine incorporation. In Water-fed groups, treatment with BPA resulted in lower titers of total IgE (P<0.01) and higher levels IgG2a (P<0.05) followed by a higher IFN-gamma (P<0.05) and IL-12 (P<0.05) with an intact IL-4. When OVA-fed groups were examined, the compound did not change production of total and OVA-specific IgE and -IgG2a but resulted in lower production of IFN-gamma (P<0.05). Also, BPA resulted in impaired lymphocyte proliferation to Con A in Water-fed groups (P<0.05) but not in tolerated animals. The findings indicate that BPA results in augmentation of Th1 immune responses but no significant effect on an established tolerance to OVA.

1. (英) Animals
2. (英) Antibody Formation
3. (英) Cytokines
4. (英) Endocrine Disruptors
5. (英) Lymphocyte Activation
6. (英) Mice
7. (英) Mice, Inbred BALB C
8. (英) Ovalbumin
9. (英) Phenols
10. (英) T-Lymphocytes, Helper-Inducer

1. (英) Article.Affiliation: Department of Preventive Environment and Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't