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著作: [桑原 知巳]/細菌ゲノムシークエンス/[四国医学雑誌]

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EID
136817
EOID
877247
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LastModified
2017年12月4日(月) 13:55:30
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[ADMIN]
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[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須 総説·解説
言語 必須 日本語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 桑原 知巳
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Determination of whole DNA sequences of bacterial genomes

(日) 細菌ゲノムシークエンス

副題 任意
要約 任意

(日) Bacteria exhibit unique biological characteristics at species or strain levels, and it has becomepossible to understand their diversities by analyzing whole genome sequences. Almost 200bacterial genome sequences have so far been published, and determination of the completegenomes of nearly500bacteria is now in progress. Developments in sequencing technology andimprovements in automated sequencers have contributed to the rapid accumulation of genomesequence data.Comparative analysis of bacterial genomes has revealed that there are extensive diversities intheir structures such as linear chromosomes of Borrelia burgdorferi and two chromosomes of thegenus Vibrio. The diversities have been established by a combination of horizontal gene transfer,gene duplication, deletion, and/or genomic rearrangements during the process of adaptation over along period to each environment. These changes in bacterial genomes, especially in pathogenicbacteria, are related to the occurrence of novel types of infection or multi‐drug resistance. On theother hand, genomic analysis of a gut commensal, Bacteroides fragilis, has revealed that this speciesdynamically changes the genomic structure within a short period of time by multiple DNAinversions that create diverse surface antigenicities to evade the host immune system. Thus,whole genome sequencing provides important information on adaptation strategies of eachbacterium. However, in an environmental ecosystem such as soil, water, and human microflora, alarge number of bacteria interact with each other and comprise a functional unit. Communitygenomics, which targets all of the bacterial genome sequences included in a particularenvironmental ecosystem, is expected to provide novel insights into microbe‐microbe and hostmicrobeinteractions.

キーワード 推奨
  1. (英) bacterial genomics
  2. (英) whole genome sequencing
  3. (英) adaptation
発行所 推奨 徳島医学会
誌名 必須 四国医学雑誌([徳島医学会])
(pISSN: 0037-3699)
ISSN 任意 0037-3699
ISSN: 0037-3699 (pISSN: 0037-3699)
Title: 四国医学雑誌
Supplier: 徳島大学
Publisher: Tokushima Igakkai
 (Webcat Plus  (医中誌Web  (Scopus (Scopus information is found. [need login])
必須 60
必須 5-6
必須 124 132
都市 任意
年月日 必須 2004年 12月 20日
URL 任意 http://ci.nii.ac.jp/naid/40006671025/
DOI 任意
PMID 任意
NAID 任意 40006671025
WOS 任意
Scopus 任意
機関リポジトリ 44165
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意