徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: 伊藤 利明/[桑原 知巳]/Suzuki Takayoshi/Hayashi Makoto/[大西 克成]/Regional mutagenicity of heterocyclic amines in the intestine: mutation analysis of the cII gene in lambda/lacZ transgenic mice/[Mutation Research]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
136803
EOID
690035
Map
0
LastModified
2013年6月8日(土) 19:07:30
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Itoh Toshiaki / (日) 伊藤 利明 / (読) いとう としあき
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 桑原 知巳
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Suzuki Takayoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Hayashi Makoto
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 大西 克成
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Regional mutagenicity of heterocyclic amines in the intestine: mutation analysis of the cII gene in lambda/lacZ transgenic mice

副題 任意
要約 任意

(英) Transgenic mouse assays have revealed that the mouse intestine, despite its resistance to carcinogenesis, is sensitive to the mutagenicity of some heterocyclic amines (HCAs). Little is known, however, about the level and localization of that sensitivity. We assessed the mutagenicity of four orally administered (20 mg/kg per day for 5 days) HCAs-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) hydrochloride, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) acetate-in the intestine of male MutaMice. Two weeks after the last administration, we isolated epithelium from the small intestine, cecum, and colon and analyzed lacZ and cII transgene mutations. PhIP increased the lacZ mutant frequency (MF) in all the samples, and in the small intestine, cII and lacZ MFs were comparable. In the cII gene, G:C to T:A and G:C to C:G transversions were characteristic PhIP-induced mutations (which has also been reported for the rat colon, where PhIP is carcinogenic). In the small intestine, PhIP increased the cII MF to four-fold that of the control, but IQ, MeIQ, and Trp-P-2 did not have a significant mutagenic effect. In the cecum, cII MFs induced by IQ and MeIQ were 1.9 and 2.7 times those in the control, respectively. The MF induced by MeIQ in the colon was 3.1 times the control value. Mutagenic potency was in the order PhIP>MeIQ>IQ; Trp-P-2 did not significantly increase the MF in any tissue. The cecum was the most susceptible organ to HCA mutagenicity.

キーワード 推奨
  1. (英) Heterocyclic amine
  2. (英) lacZ
  3. (英) Lambda cII
  4. (英) Mutant frequency
  5. (英) Intestine
発行所 推奨 Elsevier Science B.V.
誌名 必須 Mutation Research([Elsevier])
(pISSN: 0027-5107, eISSN: 1873-135X)
ISSN 任意 0027-5107
ISSN: 0027-5107 (pISSN: 0027-5107, eISSN: 1873-135X)
Title: Mutation research
Title(ISO): Mutat Res
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 539
必須 1-2
必須 99 108
都市 任意
年月日 必須 2003年 8月 5日
URL 任意 http://dx.doi.org/10.1016/S1383-5718(03)00134-7
DOI 任意 10.1016/S1383-5718(03)00134-7    (→Scopusで検索)
PMID 任意 12948818    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Molecular Bacteriology, Graduate School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't