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著作: Chewonarin Teera/Kinouchi Takemi/[片岡 佳子]/[有持 秀喜]/[桑原 知巳]/Vinitketkumnuen Usanee/[大西 克成]/Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in F344 rats/[Food and Chemical Toxicology]

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EID
136783
EOID
799440
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0
LastModified
2015年9月23日(水) 19:14:26
Operator
大家 隆弘
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TRUE
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Owner
片岡 佳子
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
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学究種別 推奨
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著者 必須
  1. (英) Chewonarin Teera
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    学籍番号 推奨
  2. (英) Kinouchi Takemi
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  3. 片岡 佳子([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.微生物・遺伝子解析学])
    役割 任意
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    学籍番号 推奨
  4. 有持 秀喜([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
    役割 任意
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    学籍番号 推奨
  5. 桑原 知巳
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  6. (英) Vinitketkumnuen Usanee
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    学籍番号 推奨
  7. 大西 克成
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題名 必須

(英) Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in F344 rats

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(英) The 80% ethanol extract of roselle (Hibiscus sabdariffa Linn.), a medicinal plant in Thailand, was examined for antimutagenic and chemopreventive activity in a colon carcinogenesis model. It reduced about 60-90% of the mutagenicity induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and other heterocyclic amines 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline(MelQ),2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline(MelQx),3-amino-1,4-dimet hyl-5H-pyrido[4,3-b]indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2),2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1),2-aminodipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2), at a concentration of 12.5 mg/plate in the Salmonella mutation assay. The extract showed no mutagenicity and no antibacterial activity below this dose. Mutagenicity of methylazoxymethanol (MAM) acetate, which, like PhIP, is a colon carcinogen,was also efficiently inhibited by the roselle extract. To investigate chemoprevention by roselle in a colon carcinogenesis model, we examined the inhibitory effects of the roselle extract in F344 rats in which aberrant crypt focus (ACF) formation was induced by azoxymethane (AOM) and PhIP. In the initiation stage, the number of AOM-induced ACF in the colon was significantly decreased by roselle (17-25%) compared with that in rats treated with AOM alone. The amount of O6-methylguanine in the colonic mucosa tended to be decreased in the roselle-treated rats. The number of PhIP-induced ACF was also significantly decreased by roselle treatment (22%) at a concentration of 1.0 g/kg body weight in the initiation stage. However, in the post-initiation stage of AOM-induced ACF formation, roselle increased the number of ACF, especially the number of foci which had more than three crypts/focus. These results indicate that roselle has antimutagenic activity against MAM acetate and heterocyclic amines and that it decreases the number of AOM- and PhIP-induced ACF in the initiation stage, although it rather increased the number of ACF in the post-initiation stage.

キーワード 推奨
  1. (英) roselle
  2. (英) chemoprevention
  3. (英) colon cancer
  4. (英) azoxymethane
  5. (英) aberrant crypt foci
  6. (英) heterocyclic amines
  7. (英) medicinal plant
  8. (英) antimutagenicity
  9. (英) PhIP
  10. (英) Hibiscus sabdariffa
発行所 推奨 Elsevier Science
誌名 必須 Food and Chemical Toxicology(British Industrial Biological Research Association)
(pISSN: 0278-6915, eISSN: 1873-6351)
ISSN 任意 0278-6915
ISSN: 0278-6915 (pISSN: 0278-6915, eISSN: 1873-6351)
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Title(ISO): Food Chem Toxicol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 37
必須 6
必須 591 601
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年月日 必須 1999年 6月 初日
URL 任意 http://dx.doi.org/10.1016/S0278-6915(99)00041-1
DOI 任意 10.1016/S0278-6915(99)00041-1    (→Scopusで検索)
PMID 任意 10478827    (→Scopusで検索)
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  1. (英) Article.PublicationTypeList.PublicationType: Journal Article