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著作: NARIOKA JUNJI/NISHI MASAHARU/OGATA YORIHIKO/[桑原 知巳]/[中山 治之]/TASHIRO SEIKI/OHNISHI YOSHINARI/Promotion of bacterial translocation by major liver resection in obstructive jaundice in rats colonised predominantly with indigenous Escherichia coli/[Journal of Medical Microbiology]

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EID
136757
EOID
876419
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LastModified
2017年11月28日(火) 17:52:14
Operator
大家 隆弘
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Owner
[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) NARIOKA JUNJI
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) NISHI MASAHARU
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) OGATA YORIHIKO
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 桑原 知巳
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 中山 治之
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) TASHIRO SEIKI
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) OHNISHI YOSHINARI
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Promotion of bacterial translocation by major liver resection in obstructive jaundice in rats colonised predominantly with indigenous Escherichia coli

副題 任意
要約 任意

(英) The influence of major liver resection in obstructive jaundice on bacterial translocation was evaluated in rats that were colonised predominantly with a genetically labelled strain of Escherichia coli. The strain, JNW14, originally isolated from rat faeces, was labelled with bacitracin, neomycin and streptomycin resistance markers. Fifty-two specific-pathogen-free male Wistar rats were divided into three experimental groups and were treated as follows: group 1 (n = 8), sham ligation of common bile duct; group 2 (n = 7), common bile duct ligation (CBDL); and group 3 (n = 37), 70% hepatectomy 7 days after CBDL. The rats were treated with the above antibiotics and then given E. coli strain JNW14 in their drinking water. Translocation of E. coli JNW14 from the gastrointestinal tract to the mesenteric lymph nodes (MLNs), lungs, liver, spleen and portal vein was evaluated in each group. In group 3 (CBDL plus hepatectomy), the incidence of translocation of E. coli JNW14 to the liver and spleen after hepatectomy was significantly higher than in groups 1 and 2. This result indicates that major liver resection in obstructive jaundice promotes bacterial translocation to systemic organs. Furthermore, the numbers of viable E. coli JNW14 in the MLNs in the lung culture-positive rats were significantly higher than those in the lung culture-negative rats, suggesting that lymphatic-thoracic duct systemic circulation is a major route of bacterial translocation.

キーワード 推奨
  1. (英) MESENTERIC LYMPH-NODES
  2. (英) GASTRO-INTESTINAL TRACT
  3. (英) MULTIPLE-ORGAN FAILURE
  4. (英) GASTROINTESTINAL TRACTS
  5. (英) HEPATIC RESECTION
  6. (英) BILIARY SURGERY
  7. (英) GUT
  8. (英) MICE
  9. (英) BILE
  10. (英) SEPSIS
発行所 推奨 Society for General Microbiology
誌名 必須 Journal of Medical Microbiology(Pathological Society of Great Britain and Ireland/[Society for General Microbiology])
(pISSN: 0022-2615, eISSN: 1473-5644)
ISSN 任意 0022-2615
ISSN: 0022-2615 (pISSN: 0022-2615, eISSN: 1473-5644)
Title: Journal of medical microbiology
Title(ISO): J Med Microbiol
Publisher: Microbiology Society [PENDING]
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 51
必須 8
必須 687 694
都市 任意
年月日 必須 2002年 8月 初日
URL 任意 http://jmm.sgmjournals.org/cgi/content/abstract/51/8/687
DOI 任意
PMID 任意 12171301    (→Scopusで検索)
NAID 任意
WOS 任意 000177188300011
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Bacteriology, School of Medicine, The University of Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't