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著作: Ogata Yorihiko/Nishi Masaharu/[中山 治之]/[桑原 知巳]/Ohnishi Yoshinari/Tashiro Seiki/Role of bile in intestinal barrier function and its inhibitory effect on bacterial translocation in obstructive jaundice in rats/[The Journal of Surgical Research]

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[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Ogata Yorihiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Nishi Masaharu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 中山 治之
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 桑原 知巳
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Ohnishi Yoshinari
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Tashiro Seiki
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Role of bile in intestinal barrier function and its inhibitory effect on bacterial translocation in obstructive jaundice in rats

副題 任意
要約 任意

(英) Our previous study using genetically labeled Escherichia coli strain JNW14 revealed that obstructive jaundice promotes bacterial translocation in rats and that the absence of bile in the intestinal tract is considered to be a factor inducing bacterial translocation. The aim of this study was to investigate the role of bile and bile acids in intestinal barrier function against bacterial translocation. Eight-week-old male specific-pathogen-free Wistar rats were subjected to ligation of their common bile ducts (CBDL). The CBDL rats were treated with bacitracin, neomycin sulfate, and streptomycin sulfate, and the intestinal tract was colonized with E. coli strain JNW14, which was genetically labeled with resistant markers against the above three antibiotics, to monitor the bacterial translocation. The rats were then administered saline, cholic acid (20 mg/100 g BW), taurocholic acid (TCA: 5-50 mg/100 BW), or bile (1.5-6 mL/day) via a duodenal catheter. The degree of bacterial translocation of E. coli strain JNW14 to the mesenteric lymph nodes was compared. Histopathological examination of the terminal ileum and intestinal permeability test using phenolsulfonphthalein was also performed. Both cholic acid and TCA showed no inhibitory effect on bacterial translocation at any of the doses tested in CBDL rats, although TCA significantly decreased the numbers of E. coli strain JNW14 in the cecum. However, bile administration reduced the numbers of E. coli strain JNW14 in the cecum and mesenteric lymph nodes in CBDL rats although the inhibitory effect was weak. The integrity and permeability of the intestinal mucosa were kept at normal levels by bile administration in CBDL rats whereas the morphological changes, such as villous atrophy, villous edema, and lacteal canal dilatation, were observed in other CBDL rats. Bile plays an important role in maintaining the intestinal barrier function to prevent the invasion of enteric bacteria to the underlying tissues, suggesting that the intestinal administration of bile to patients with obstructive jaundice is a useful way to reduce infectious complications by inhibiting bacterial translocation from the intestine to other organs.

キーワード 推奨
  1. (英) bile
  2. (英) bile acid
  3. (英) JNW14
  4. (英) bacterial translocation
  5. (英) obstructive jaundice
発行所 推奨 Elsevier(->組織[Elsevier Science])
誌名 必須 The Journal of Surgical Research(Association for Academic Surgery (U.S.)/Association of Veterans Administration Surgeons (U.S.))
(pISSN: 0022-4804, eISSN: 1095-8673)
ISSN 任意 0022-4804
ISSN: 0022-4804 (pISSN: 0022-4804, eISSN: 1095-8673)
Title: The Journal of surgical research
Title(ISO): J Surg Res
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 115
必須 1
必須 18 23
都市 任意
年月日 必須 2003年 11月 初日
URL 任意
DOI 任意 10.1016/S0022-4804(03)00308-1    (→Scopusで検索)
PMID 任意 14572768    (→Scopusで検索)
NAID 任意
WOS 任意 000186125300003
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Digestive Surgery, Graduate School of Medicine, University of Tokushima, Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't