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著作: Namekata Kazuhiko/[西村 範行]/Kimura Hideo/Presenilin-binding protein forms aggresomes in monkey kidney COS-7 cells/[Journal of Neurochemistry]

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EID
136728
EOID
679649
Map
0
LastModified
2013年2月22日(金) 15:52:14
Operator
松井 栄里
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TRUE
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Owner
[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Namekata Kazuhiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 西村 範行
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Kimura Hideo
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Presenilin-binding protein forms aggresomes in monkey kidney COS-7 cells

副題 任意
要約 任意

(英) A novel presenilin-binding protein (PBP) is specifically expressed in the brain, and its level in the soluble fraction of Alzheimer's disease (AD) brains is much less than that in the age-matched controls. Recently, several proteins, including presenilin (PS), have been found to form structures of aggregated proteins, called aggresomes, when the production of the proteins exceeds their rate of degradation by proteasomes. Based on these observations it has been proposed that the aggresome may represent one of the mechanisms forthe formation of cytoplasmic deposits which are linked to the pathogenesis of neurodegenerative disorders including AD. It is shown here that the overexpression of PBP or the suppression of proteasome activity in monkey kidney COS-7 cells leads to the accumulation of detergent-insoluble and multiubiquitinated PBP aggregates. PBP also forms aggregates in primary cultures of neurons in the presence of a proteasome inhibitors. PBP aggregates have the characteristics of aggresomes, including the localization to microtubule organization centers and the disruption of intermediate filaments. These observations suggest that the malfunctioning of the proteasome can cause the formation of PBP aggresomes, which may lead to AD.

キーワード 推奨
  1. (英) aggresome
  2. (英) Presenilin-binding protein
  3. (英) proteasome
  4. (英) ubiquitin
発行所 推奨 The International Society for Neurochemistry
誌名 必須 Journal of Neurochemistry([The International Society for Neurochemistry])
(pISSN: 0022-3042, eISSN: 1471-4159)
ISSN 任意 0022-3042
ISSN: 0022-3042 (pISSN: 0022-3042, eISSN: 1471-4159)
Title: Journal of neurochemistry
Title(ISO): J Neurochem
Supplier: International Society for Neurochemistry
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 82
必須 4
必須 819 827
都市 任意
年月日 必須 2002年 8月 初日
URL 任意 http://www.blackwell-synergy.com/doi/abs/10.1046/j.1471-4159.2002.01039.x
DOI 任意 10.1046/j.1471-4159.2002.01039.x    (→Scopusで検索)
PMID 任意 12358787    (→Scopusで検索)
NAID 任意 30014568822
WOS 任意 000177369300010
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: National Institute of Neuroscience, NCNP, Tokyo, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't