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著作: Kageyama N/[野村 昌弘]/[中屋 豊]/Watanabe T/[伊東 進]/Relationship between adhesion molecules with hs-CRP and changes therein after ARB (Valsartan) administration in patients with obstructive sleep apnea syndrome/[The Journal of Medical Investigation : JMI]

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EID
136628
EOID
878468
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0
LastModified
2017年12月4日(月) 14:07:50
Operator
[ADMIN]
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Owner
[学科長]/[徳島大学.医学部.医科栄養学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kageyama N
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 野村 昌弘
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 中屋 豊
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Watanabe T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 伊東 進
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Relationship between adhesion molecules with hs-CRP and changes therein after ARB (Valsartan) administration in patients with obstructive sleep apnea syndrome

副題 任意
要約 任意

(英) It has been reported that a relationship exists between obstructive sleep apnea syndrome (OSAS) and cardiovascular and cerebrovascular diseases. To address this issue, we evaluated whether OSAS is associated with adhesion molecules and inflammatory signs, important indicators of atherosclerosis. Levels of high-sensitivity CRP (hs-CRP) and intercellular adhesion molecule-1 (ICAM-1) were measured in 30 patients with ischemic heart disease, confirmed by coronary arteriography (IHD group). Twenty healthy volunteers without sleep apnea were used as controls (Group N). Sleeping respiratory information was collected using a portable sleep polygraph, together on information about oronasal flow, tracheal sound, chest respiration, and percutaneous oxygen saturation (SpO2) to obtain the apnea-hypopnea index (AHI). In the IHD group, 9 (30%) of the 30 patients showed evidence of OSAS [IHD(AHI> or = 40) group] and 21 did not [IHD(AHI<40) group]. The levels of hs-CRP and ICAM-1 were significantly higher in the IHD group than in the N group (p<0.01). Moreover, the levels of hs-CRP and ICAM-1 were significantly higher in the IHD(AHI > or = 40) group than in the IHD(AHI<40) group (p<0.01). However, after the administration of valsartan, angiotensin II receptor antagonists (ARB) to both IHD groups, the levels of hs-CRP and ICAM-1 decreased significantly in both groups. Moreover, a multivariate analysis revealed that the levels of hs-CRP and ICAM-1 were associated with the severity of sleep apnea. These findings suggest that, in OSAS the levels of hs-CRP and ICAM-1 are decreased and that the administration of ARB decreases the risk of atherosclerosis.

キーワード 推奨
  1. (英) Aged
  2. (英) Angiotensin II Type 1 Receptor Blockers
  3. (英) Arteriosclerosis
  4. (英) C-Reactive Protein
  5. (英) Case-Control Studies
  6. (英) Female
  7. (英) Humans
  8. (英) Intercellular Adhesion Molecule-1
  9. (英) Interleukin-6
  10. (英) Male
  11. (英) Middle Aged
  12. 心筋虚血(myocardial ischemia)
  13. (英) Sleep Apnea, Obstructive
  14. (英) Tetrazoles
  15. (英) Valine
発行所 推奨
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 53
必須 1,2
必須 134 139
都市 任意
年月日 必須 2006年 2月 初日
URL 任意
DOI 任意 10.2152/jmi.53.134    (→Scopusで検索)
PMID 任意 16538006    (→Scopusで検索)
NAID 任意 110004748844
WOS 任意
Scopus 任意 2-s2.0-33645811958
機関リポジトリ 110798
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article