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著作: Takagawa Mayuko/[六車 直樹]/Oguri Kaori/井本 佳孝/[岡本 耕一]/II Kunio/[伊東 進]/Prediction of Prognosis in Gallbladder Carcinoma by Mucin and p53 Immunohistochemistry/[Digestive Diseases and Sciences]

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EID
136589
EOID
794465
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LastModified
2015年8月31日(月) 15:48:56
Operator
三木 ちひろ
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六車 直樹
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.病院.診療科.内科(2003年10月1日〜)
  2. 徳島大学.大学院ヘルスバイオサイエンス研究部.発達予防医歯学部門.病態予防医学講座(2004年4月1日〜)
著者 必須
  1. (英) Takagawa Mayuko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 六車 直樹([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Oguri Kaori
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Imoto Yoshitaka / (日) 井本 佳孝 / (読) いもと よしたか
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 岡本 耕一([徳島大学.病院.診療科.内科.消化器内科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) II Kunio
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 伊東 進
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Prediction of Prognosis in Gallbladder Carcinoma by Mucin and p53 Immunohistochemistry

副題 任意
要約 任意

(英) Mucin core proteins are known to be present in various organs and are specifically expressed with carcinogenesis and closely associated with the prognoses of various malignant tumors in the digestive tract such as colorectal cancer. The present study evaluated correlations between mucin and p53 expression and prognosis of gallbladder cancer using surgically resected tissue specimens from 26 patients with gallbladder carcinoma surgically treated at our hospital. Immunohistochemical staining was performed using MUC 1, MUC2, and p53 monoclonal antibody. The level of antigen expression in the lesion was classified into four stages: none(-), slight(+), moderate (++), and severe (+ + +). According to the UICC classification, histopathological grading, levels of T, N, and M factors, and tumor stages were compared with regard to the correlations with mucin and p53 expression. All cases were classified into two groups according to the results of mucin immunohistochemistry: group A (MUC1, > or = ++; and MUC2, < or = +) and group B (MUC1, < ++; or MUC2, > +). Postoperative survival periods were compared between the two groups and p53-positive and -negative groups. Neither histological grading nor T factor correlated with mucin or p53 expression, respectively. Moreover, neither N factor nor M factor correlated with mucin or p53 expression. Furthermore, stage grouping did not correlate with mucin or p53 expression. However, when the correlation between the postoperative survival period and mucin expression was evaluated, the mean postoperative surgical period was significantly shorter in Group A than in Group B (1.02 years in Group A vs 2.92 years in Group B; P = 0.016). There was no relationship between postoperative survival period and p53 positivity. Mucin expression was independent of various tumor growth factors and clearly reflected the prognosis of gallbladder cancer. Because the relative malignancy of gallbladder cancer could be evaluated by examining the level of glycoprotein expression in tumor tissue, mucin could be a more important marker than p53 for predicting prognosis in gallbladder carcinoma using surgically resected tissue specimens.

キーワード 推奨
  1. (英) gallbladder carcinoma
  2. (英) mucin
  3. (英) p53
  4. (英) prognosis
発行所 推奨 Springer-Verlag
誌名 必須 Digestive Diseases and Sciences(Gastroenterology Research Group)
(pISSN: 0163-2116, eISSN: 1573-2568)
ISSN 任意 0163-2116
ISSN: 0163-2116 (pISSN: 0163-2116, eISSN: 1573-2568)
Title: Digestive diseases and sciences
Title(ISO): Dig Dis Sci
Supplier: Kluwer Online
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 50
必須 8
必須 1410 1413
都市 任意 (英) Netherlands
年月日 必須 2005年 8月 初日
URL 任意 http://www.springerlink.com/link.asp?id=g8263172v03684x4
DOI 任意 10.1007/s10620-005-2854-8    (→Scopusで検索)
PMID 任意 16114133    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine, Tokushima City, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article