徳島大学 教育・研究者情報データベース(EDB)

1. 勢井 宏義([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.生理学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) Update on Research for Sleep and Circadian Rhythm

(日) 睡眠と生体リズムの最新の知見

(日) Slow wave activity(SWA:<4Hz)in electroencephalograms(EEG)appears during non-REMsleep, which is regulated homeostatically, increasing after wakefulness and returning to baselineduring sleep. Recently, it has been suggested that SWA homeostasis may reflect synaptic changesunderlying a cellular need for sleep. Huber et al.(Nature，430(6995):78‐81，2004)have shownthat SWA homeostasis has a local component, which can be triggered by a learning task involvingspecific brain regions. We also found an impaired SWA rebound after sleep deprivation in fmr1(fragile-X syndrome mental retardation1)knockout mice, indicating an involvement of fmr1genein neural plasticity.Clock genes regulating circadian rhythm are recently thought to modulate several brainfunctions. Spanagel et al.(Nature Medicine，11(1):35‐42，2004)have shown that per2mutantmice show alterations in the glutamatergic system in the brain, accompanied by increasing alcoholintake. They also found that, in humans, genetic variations of human per 2 are related to thealcohol consumption Furthermore, clock genes have been indicated to have important roles in notonly brain but also peripheral organs.In future, we need an animal model for"insomnia"which is one of the most common sleepdisorders in humans.

1. 睡眠(sleep)
2. (英) Slow Wave Activity
3. (英) Learning
4. (英) Circadian
5. (英) Clock Genes