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著作: [細川 義隆]/[細川 育子]/[尾崎 和美]/[中江 英明]/[村上 圭史]/[三宅 洋一郎]/[松尾 敬志]/CXCL12 and CXCR4 expression by human gingival fibroblasts in periodontal disease/[Clinical and Experimental Immunology]

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EID
136381
EOID
695553
Map
0
LastModified
2013年7月19日(金) 18:44:27
Operator
細川 義隆
Avail
TRUE
Censor
0
Owner
三宅 洋一郎
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 細川 義隆([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 細川 育子([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 尾崎 和美([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 中江 英明
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 村上 圭史([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 三宅 洋一郎
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 松尾 敬志
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) CXCL12 and CXCR4 expression by human gingival fibroblasts in periodontal disease

副題 任意
要約 任意

(英) CXCL12 is a CXC chemokine that is related to lymphocyte infiltration and angiogenesis in inflammatory sites such as arthritis. However, the expression and roles of CXCL12 in periodontal disease are uncertain. The aim of this study was to assess the expression of CXCL12 and its receptor, CXCR4, in periodontal tissue and to investigate the properties of CXCL12 and CXCR4 expression by human gingival fibroblasts (HGF). RT-PCR analysis revealed that CXCL12 and CXCR4 mRNA were expressed in both normal gingival tissues and periodontal diseased tissues. Immunohistochemistry disclosed that CXCL12 was expressed and CXCR4 positive cells were found in both normal and periodontal diseased gingival tissues. Our in vitro experiments elucidated that HGF constitutively produced CXCL12, and the levels were enhanced by stimulation with tumour necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), transforming growth factor-beta (TGF-beta), regulated upon activation normal T cell expressed and secreted (RANTES) and macrophage inflammatory protein 3(alpha) (MIP-3(alpha)). On the other hand, heat killed Porphyromonas gingivalis (P. gingivalis) and P. gingivalis LPS reduced the CXCL12 production by HGF. Flow cytometry analysis clarified that CXCR4 was highly expressed on HGF, and CXCR4 expression was abrogated by TNF-alpha, IFN-gamma and P. gingivalis LPS. Moreover, CXCL12 induced vascular endothelial growth factor (VEGF) production by HGF. Our results demonstrated that CXCL12 might be related to CXCR4+ cells infiltration and angiogenesis both in normal periodontal tissues and periodontal diseased tissue. P. gingivalis, a known periodontal pathogen, inhibits the production of CXCL12 and the expression of CXCR4 by HGF. This fact means that P. gingivalis may inhibit CXCR4+ cells infiltration and neovascularization in periodontal tissue and escape from the immune response.

キーワード 推奨
  1. (英) CXCL12
  2. (英) CXCR4
  3. (英) fibroblast
  4. 歯周炎(periodontal disease)
  5. (英) Porphyromonas gingivalis
発行所 推奨
誌名 必須 Clinical and Experimental Immunology(British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)
ISSN 任意 0009-9104
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 141
必須 3
必須 467 474
都市 任意
年月日 必須 2005年 9月 初日
URL 任意 http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2249.2005.02852.x
DOI 任意 10.1111/j.1365-2249.2005.02852.x    (→Scopusで検索)
PMID 任意 16045736    (→Scopusで検索)
NAID 任意
WOS 任意 000230628300011
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. hosokawa@dent.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) OtherID: PMC1809465