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著作: [林 良夫]/Haneji N/Yanagi K/Higashiyama H/Yagita H/Hamano H/Prevention of adoptive transfer of murine Sjogren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1)/[Clinical and Experimental Immunology]

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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 林 良夫
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Haneji N
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Yanagi K
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Higashiyama H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Yagita H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Hamano H
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Prevention of adoptive transfer of murine Sjogren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1)

副題 任意
要約 任意

(英) We have analysed the role of ICAM-1 and LFA-1 during development of autoimmune sialadenitis in MRL/lpr mice by direct analysis of RNA obtained from the salivary gland tissues, and the therapeutic effects with antibody administration on adoptive transfer system into SCID mice. The expression of cell adhesion molecules was assessed by using reverse transcriptase polymerase chain reaction (RT-PCR) and Southern blot analysis, and immunohistochemical analysis. Up-regulated expression of ICAM-1 mRNA was observed before the onset of inflammatory lesions in the salivary glands at 1 month and 2 months old, and thereafter LFA-1 mRNA was expressed within the typical inflammatory lesions, resembling human Sjögren's syndrome in MRL/lpr mice. Immunohistochemically, ICAM-1 was localized exclusively in the endothelial cells of varying sized blood vessels before the onset of disease, and LFA-1 expressing inflammatory cells were found within these lesions. When the therapeutic effects in vivo were examined, antibodies to ICAM-1 in combination with anti-LFA-1 prevented adoptive transfer of Sjögren's syndrome in MRL/lpr mice into SCID mice, while no significant effect was found when treated with either antibody. These findings indicate that in Sjögren's syndrome-like autoimmune lesions in MRL/lpr mice the ICAM-1/LFA-1 pathway may play a crucial role in the initiation and subsequent progression of T cell-mediated autoimmunity in the salivary and lacrimal glands of MRL/lpr mice.

キーワード 推奨
  1. シェーグレン症候群(Sjögren's syndrome)
  2. (英) Adoptive Transfer
  3. (英) Adhesion Molecules
  4. (英) Prevented Effect
  5. (英) SCID mice
発行所 推奨 (英) Blackwell Science
誌名 必須 Clinical and Experimental Immunology(British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)
ISSN 任意 0009-9104
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 102
必須 2
必須 360 367
都市 任意
年月日 必須 1995年 11月 初日
URL 任意
DOI 任意
PMID 任意 7586691    (→Scopusで検索)
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指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article

  2. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  3. (英) OtherID: PMC1553424