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著作: 田中 英治/大木 崇/[田畑 智継]/[山田 博胤]/原田 顕治/木村 恵理子/大石 佳史/Ishimoto Takeo/[伊東 進]/Losartan improves regional left ventricular systolic and diastolic function in patients with hypertension/[Journal of Cardiac Failure]

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EID
135311
EOID
657529
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0
LastModified
2012年9月3日(月) 21:26:28
Operator
大家 隆弘
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TRUE
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Owner
山田 博胤
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.病院.診療科.内科(2003年10月1日〜)
著者 必須
  1. (英) Tanaka Hideji / (日) 田中 英治 / (読) たなか ひでじ
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Oki Takashi / (日) 大木 崇 / (読) おおき たかし
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 田畑 智継
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 山田 博胤([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Harada Kenji / (日) 原田 顕治 / (読) はらだ けんじ
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Kimura Eriko / (日) 木村 恵理子 / (読) きむら えりこ
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Oishi Yoshifumi / (日) 大石 佳史 / (読) おおいし よしふみ
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Ishimoto Takeo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 伊東 進
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Losartan improves regional left ventricular systolic and diastolic function in patients with hypertension

副題 任意

(英) Accurate evaluation using a newly developed color-coded tissue Doppler imaging technique

要約 任意

(英) Angiotensin II receptor antagonists have recently been accepted as antihypertensive therapy. Tissue Doppler imaging (TDI) has been developed as a noninvasive tool to assess quantitatively regional myocardial motion abnormalities. This study was designed to determine whether our newly developed technique of color-coded TDI may be a useful means of quantifying the improvement in regional left ventricular (LV) myocardial contractility and relaxation after treatment with losartan in patients with hypertension. Losartan (50 to 100 mg) was administered for 6 months to 37 previously untreated patients with essential hypertension. Averaged myocardial velocity profiles (MVPs) for color-coded TDI were recorded in the ventricular septum and LV posterior wall before and after treatment. Peak myocardial velocities and peak myocardial velocity gradients (MVGs) in the LV walls were determined during systole and early diastole. The plasma concentration of transforming growth factor (TGF)-beta1 also was measured in all patients. Blood pressure and plasma TGF-beta1 level decreased after initiation of losartan therapy. The LV mass index and LV meridional end-systolic wall stress also decreased after treatment with losartan. LV geometry changed from a pattern consistent with concentric hypertrophy to normal geometry in 10 patients and to a pattern consistent with concentric remodeling in 5 patients, and from concentric remodeling to normal geometry in 5 patients after treatment with losartan. The ratio of early to late diastolic filling for the transmitral flow velocity increased after losartan treatment. The peak systolic and early diastolic myocardial velocities and MVGs in the ventricular septum and LV posterior wall increased after treatment with losartan, although the values 6 months after treatment with losartan were still lower than those in normal individuals. There were good correlations between changes in plasma TGF-beta1 level and changes in systolic and early diastolic MVGs 6 months after losartan. However, there were no significant correlations between changes in the systolic blood pressure and LV end-systolic wall stress and changes in the TDI parameters. Losartan improves regional LV function in patients with hypertension. Our newly developed averaged MVP and MVG measurements may be useful for accurately evaluating regional LV myocardial contractility and relaxation in these patients.

キーワード 推奨
  1. (英) Aged
  2. (英) Angiotensin II Type 2 Receptor Blockers
  3. (英) Antihypertensive Agents
  4. (英) Diastole
  5. (英) Echocardiography, Doppler
  6. (英) Female
  7. (英) Humans
  8. (英) Hypertension
  9. (英) Losartan
  10. (英) Male
  11. (英) Middle Aged
  12. (英) Regression Analysis
  13. (英) Systole
  14. (英) Treatment Outcome
  15. (英) Ventricular Function, Left
発行所 推奨
誌名 必須 Journal of Cardiac Failure(Heart Failure Society of America/Japanese Heart Failure Society)
(pISSN: 1071-9164, eISSN: 1532-8414)
ISSN 任意 1071-9164
ISSN: 1071-9164 (pISSN: 1071-9164, eISSN: 1532-8414)
Title: Journal of cardiac failure
Title(ISO): J Card Fail
Publisher: Churchill Livingstone
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 10
必須 5
必須 412 420
都市 任意
年月日 必須 2004年 10月 初日
URL 任意 http://dx.doi.org/10.1016/j.cardfail.2004.01.007
DOI 任意 10.1016/j.cardfail.2004.01.007    (→Scopusで検索)
PMID 任意 15470652    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Digestive and Cardiovascular Medicine, School of Medicine, The University of Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article