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著作: [山田 博胤]/Martin O. David/Mowrey A. Kent/Greenberg L. Neil/Wallick W. Don/The Effects of Coupled Pacing on Cardiac Performance during Acute Atrial Tachycardia and Fibrillation/[American Journal of Physiology, Heart and Circulatory Physiology]

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EID
135299
EOID
691696
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0
LastModified
2013年6月20日(木) 21:54:12
Operator
大家 隆弘
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TRUE
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Owner
山田 博胤
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.病院.診療科.内科(2003年10月1日〜)
著者 必須
  1. 山田 博胤([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Martin O. David
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Mowrey A. Kent
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Greenberg L. Neil
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Wallick W. Don
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) The Effects of Coupled Pacing on Cardiac Performance during Acute Atrial Tachycardia and Fibrillation

副題 任意

(英) An Old Therapy Revisited for a New Reason

要約 任意

(英) Atrial tachycardia (AT) and fibrillation (AF) result in rapid ventricular rates that are detrimental to optimal cardiac function. The purpose of this study was to determine whether the application of a coupled pacing (CP) regimen would improve ventricular function by decreasing the ventricular rate of mechanical contractions (VRMCs). We simulated AT by pacing either atrium at a rate that resulted in a rapid but regular ventricular rate in seven anesthetized dogs. AF was induced by increasing the atrial pacing rate until atrial activation did not follow the pacing. After the induction of either AT or AF, we applied CP after each intrinsic ventricular activation. We measured the VRMCs and left ventricular (LV) pressures and volumes via a pressure-conductance catheter. The marked reductions in VRMCs during CP resulted in increases in LV end-diastolic volume. The CP resulted in virtually no mechanical contractions, whereas the strength of contractions from the normal electrical activation increased. The increases in the positive LV rate of pressure development over time and LV ejection fraction during CP were the result of postextrasystolic potentiation. The average stroke work (area of the pressure-volume loops) increased as a result of CP during both AT and AF. Despite the large increases in stroke volume (approximately 2x) during CP, the changes in cardiac output were moderate because the VRMCs markedly decreased (approximately 1/2). We conclude that CP therapy may be a viable therapy for slowing the heart rate and improving cardiac performance in patients with AT and AF.

キーワード 推奨
  1. (英) Acute Disease
  2. (英) Animals
  3. (英) Aorta
  4. (英) Atrial Fibrillation
  5. (英) Blood Pressure
  6. (英) Dogs
  7. (英) Electric Stimulation Therapy
  8. (英) Myocardial Contraction
  9. (英) Pacemaker, Artificial
  10. (英) Stroke Volume
  11. (英) Tachycardia, Ectopic Atrial
  12. (英) Vascular Resistance
  13. (英) Ventricular Function, Left
発行所 推奨
誌名 必須 American Journal of Physiology, Heart and Circulatory Physiology([アメリカ生理学会])
(pISSN: 0363-6135, eISSN: 1522-1539)
ISSN 任意 0363-6135
ISSN: 0363-6135 (pISSN: 0363-6135, eISSN: 1522-1539)
Title: American journal of physiology. Heart and circulatory physiology
Title(ISO): Am J Physiol Heart Circ Physiol
Publisher: American Physiological Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 285
必須 6
必須 H2630 H2638
都市 任意
年月日 必須 2003年 12月 初日
URL 任意 http://ajpheart.physiology.org/cgi/content/abstract/285/6/H2630
DOI 任意 10.1152/ajpheart.00393.2003    (→Scopusで検索)
PMID 任意 12893639    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't