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著作: Kumagai R/Oki Chie/Muramatsu Yasuko/Kurosaki Rumiko/Kato Hiroyuki/[荒木 勉]/Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, reduces hippocampal damage after transient cerebral ischemia in gerbils/[Journal of Neural Transmission]

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EID
134983
EOID
667294
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2012年10月24日(水) 18:48:41
Operator
大家 隆弘
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[学科長]/[徳島大学.薬学部.薬学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kumagai R
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Oki Chie
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Muramatsu Yasuko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Kurosaki Rumiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kato Hiroyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 荒木 勉
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, reduces hippocampal damage after transient cerebral ischemia in gerbils

副題 任意
要約 任意

(英) Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, is a potent cholesterol-lowering drug that reduces the risk of myocardial infarction and stoke. In this study, we examined its neuroprotective effects against hippocampal CA1 neuronal damage following transient cerebral ischemia in gerbils. Forebrain ischemia was induced by occlusion of bilateral common carotid arteries for 5 min. Pitavastatin, at a dose of 3, 10 or 30 mg/kg, was administered orally twice a day for 5 consecutive days and transient cerebral ischemia was induced in mice 1 h after the last treatment with pitavastatin. Histopathological observations showed that neuronal damage to the hippocampal CA1 neurons, which was observed 5 days after ischemia in animals, was prevented by pitavastatin treatment. Immunohistochemical staining for copper/zinc superoxide dismutase (SOD) and manganese SOD decreased in the hippocampal CA1 sector of gerbils 2 days after ischemia when histological neuronal destruction was not yet found, but was clearly observed in pitavastatin-treated animals. These results indicate that pitavastatin can protect dose-dependently against ischemia-induced neuronal damage and that the mechanism of the neuroprotection may be related to the preservation of SODs, especially copper/zinc-SOD. This in part explains how pitavastatin therapy, which targets free radicals, has beneficial effects against disorders including ischemic stroke.

キーワード 推奨
  1. 脳虚血(cerebral ischemia)
  2. (英) superoxide dismutase
  3. (英) neuronal damage
  4. 免疫組織化学(immunohistochemistry)
  5. (英) free radicals
  6. (英) gerbils
発行所 推奨 Springer-Verlag
誌名 必須 Journal of Neural Transmission([European Society for Clinical Neuropharmacology])
(pISSN: 0300-9564, eISSN: 1435-1463)
ISSN 任意 0300-9564
ISSN: 0300-9564 (pISSN: 0300-9564, eISSN: 1435-1463)
Title: Journal of neural transmission (Vienna, Austria : 1996)
Title(ISO): J Neural Transm (Vienna)
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 111
必須 9
必須 1103 1120
都市 任意 ウィーン(Wien/[オーストリア共和国])
年月日 必須 2004年 9月 初日
URL 任意
DOI 任意 10.1007/s00702-004-0150-y    (→Scopusで検索)
PMID 任意 15338328    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Drug Metabolism and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't