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著作: Kurosaki Rumiko/Muramatsu Yasuko/Kato Hiroyuki/[荒木 勉]/Protective effect of pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, on ischemia-induced neuronal damage/[Neurological Research]

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EID
134977
EOID
876275
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2017年11月28日(火) 17:49:36
Operator
大家 隆弘
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[学科長]/[徳島大学.薬学部.薬学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kurosaki Rumiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Muramatsu Yasuko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Kato Hiroyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 荒木 勉
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Protective effect of pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, on ischemia-induced neuronal damage

副題 任意
要約 任意

(英) We investigated the neuroprotective effects of a novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (pitavastatin) on ischemic neuronal damage in gerbils using immunohistochemistry. The animals were allowed to survive for 14 days after 5 min of ischemia induced by bilateral occlusion of the common carotid arteries. Five days after ischemia, severe neuronal cell loss was observed in the hippocampal CA1 sector. Prophylactic treatment with pitavastatin dose-dependently prevented the hippocampal CA1 neuronal cell loss 5 days after ischemia. Immunohistochemical study did not show the change of nNOS and iNOS expression in the hippocampus except for, in a few regions, up to 1 day after ischemia. Thereafter, the expression of iNOS was observed in the hippocampal CA1 sector 5 and 14 days after ischemia. In contrast, the expression of nNOS and eNOS gradually decreased in the hippocampal CA1 sector up to 14 days after ischemia. Prophylactic treatment with pitavastatin also prevented the expression of iNOS and the decrease of eNOS expression and the number of nNOS-positive cells in the hippocampal CA1 sector 5 days after ischemia. However, prophylactic treatment with pitavastatin at a dose of 10 mg kg(-1) did not change the immunoreactivity of iNOS and nNOS in the hippocampus at an early phase after ischemia. In contrast, this drug prevented the reduction of eNOS immunoreactivity in the hippocampal CA1 neurons at an early phase after ischemia. These findings demonstrate that the HMG-CoA reductase inhibitor pitavastatin can protect hippocampal CA1 neurons after transient forebrain ischemia through up-regulation of eNOS expression in this region. Thus pharmacological modulation of eNOS expression may offer a novel therapeutic strategy for cerebral ischemic stroke.

キーワード 推奨
  1. (英) TRANSIENT FOREBRAIN ISCHEMIA
  2. (英) HIPPOCAMPUS
  3. (英) NITRIC OXIDE SYNTHASE
  4. 免疫組織化学(immunohistochemistry)
  5. (英) GERBILS
発行所 推奨 (英) Maney Publishing
誌名 必須 Neurological Research(Maney Publishing)
(pISSN: 0161-6412, eISSN: 1743-1328)
ISSN 任意 0161-6412
ISSN: 0161-6412 (pISSN: 0161-6412, eISSN: 1743-1328)
Title: Neurological research
Title(ISO): Neurol Res
Publisher: Maney Publishing
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 26
必須 6
必須 684 691
都市 任意
年月日 必須 2004年 9月 初日
URL 任意 http://www.ingentaconnect.com/content/maney/nres/2004/00000026/00000006/art00012
DOI 任意 10.1179/016164104225014102    (→Scopusで検索)
PMID 任意 15327760    (→Scopusで検索)
NAID 任意
WOS 任意 000223832200012
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Drug Metabolism and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't