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著作: Kurosaki Rumiko/Muramatsu Yasuko/Imai Yutaka/Kato Hiroyuki/[荒木 勉]/Neuroprotective effect of the angiotensin-converting enzyme inhibitor perindopril in MPTP-treated mice/[Neurological Research]

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EID
134974
EOID
682443
Map
0
LastModified
2013年3月15日(金) 17:06:13
Operator
三木 ちひろ
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TRUE
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Owner
[学科長]/[徳島大学.薬学部.薬学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kurosaki Rumiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Muramatsu Yasuko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Imai Yutaka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Kato Hiroyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 荒木 勉
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Neuroprotective effect of the angiotensin-converting enzyme inhibitor perindopril in MPTP-treated mice

副題 任意
要約 任意

(英) The angiotensin -converting enzyme (ACE) inhibitor perindopril has been shown to exert beneficial effects on the dopaminergic system. Here, we investigated the effects of perindopril on the dopaminergic system in mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment, in comparison with a Ca(2+) antagonist, amlodipine. Administration of perindopril showed dose-dependent neuroprotective effects against MPTP-induced striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) depletion. However, administration of amlodipine showed no significant effects on striatal dopamine depletion after MPTP treatment. In our immunohistochemical studies with antibodies against tyrosine hydroxylase (TH), microtubule-associated protein 2a, b (MAP2), dopamine transporter (DAT), parvalbumin (PV), glial fibrillary acidic protein (GFAP) and Cu/Zn-superoxide dismutase (Cu/Zn-SOD), the administration of perindopril significantly attenuated MPTP-induced substantia nigra and striatal damage. This drug also blocked the increases in GFAP-positive astrocytes in the striatum and substantia nigra after MPTP treatment. Furthermore, the administration of perindopril showed a protective effect against the intense Cu/Zn-SOD immunoreactivity in the neurons and glial cells in both the striatum and substantia nigra after MPTP treatment. These results indicated that the ACE inhibitor perindopril can protect against MPTP-induced striatal dopamine and DOPAC depletion in mice. The protective effect may be, at least in part, caused by the reduction of free radicals caused by MPTP. The present study also demonstrated that perindopril is effective against MPTP-induced neurodegeneration of the nigro-striatal dopaminergic pathway. Furthermore, our results provided further evidence that free radical scavengers may be effective in the treatment of neurodegenerative diseases such as Parkinson's disease.

キーワード 推奨
  1. (英) ANGIOTENSIN-CONVERTING ENZYME INHIBITOR
  2. (英) MPTP
  3. 免疫組織化学(immunohistochemistry)
  4. ドーパミン(dopamine)
  5. (英) SOD
  6. (英) DOPAMINERGIC SYSTEM
発行所 推奨 (英) Maney Publishing
誌名 必須 Neurological Research(Maney Publishing)
(pISSN: 0161-6412, eISSN: 1743-1328)
ISSN 任意 0161-6412
ISSN: 0161-6412 (pISSN: 0161-6412, eISSN: 1743-1328)
Title: Neurological research
Title(ISO): Neurol Res
Publisher: Maney Publishing
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 26
必須 6
必須 644 657
都市 任意
年月日 必須 2004年 9月 初日
URL 任意 http://www.ingentaconnect.com/content/maney/nres/2004/00000026/00000006/art00006
DOI 任意 10.1179/016164104225015949    (→Scopusで検索)
PMID 任意 15327754    (→Scopusで検索)
NAID 任意
WOS 任意 000223832200006
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Drug Metabolism and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't