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著作: Watanabe Hijiri/Muramatsu Yasuko/Kurosaki Rumiko/Michimata Mari/Matsubara Mitsunobu/Imai Yutaka/[荒木 勉]/Protective effects of neuronal nitric oxide synthase inhibitor in mouse brain against MPTP neurotoxicity: an immunohistological study/[European Neuropsychopharmacology]

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134968
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657821
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2012年9月4日(火) 16:13:19
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大家 隆弘
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[学科長]/[徳島大学.薬学部.薬学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
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共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Watanabe Hijiri
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Muramatsu Yasuko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Kurosaki Rumiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Michimata Mari
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Matsubara Mitsunobu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Imai Yutaka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 荒木 勉
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Protective effects of neuronal nitric oxide synthase inhibitor in mouse brain against MPTP neurotoxicity: an immunohistological study

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(英) We recently reported that neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole, can protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice. It protected against both dopamine depletions and tyrosine hydroxylase (TH) positive neuron decreases in the mouse brain. In the present study, we further examined whether 7-nitroindazole can also protect against the alterations of TH-, microtubule-associated protein 2a,b (MAP2)-, glial fibrillary acidic protein (GFAP)-, parvalbumin (PV)-, dopamine transporter (DAT)-, nNOS- or endothelial NOS (eNOS)-positive cells, in comparison with pargyline as a relatively selective inhibitor of the monoamine oxidase-B (MAO-B). The present study showed that nNOS inhibitor as well as MAO-B inhibitor has a dose-dependent protective effect against MPTP-induced striatal dopamine and DOPAC depletion in mice. Furthermore, the present study revealed that 7-nitroindazole and pargyline can protect the alterations of immunohistochemical changes in the striatum and substantia nigra after MPTP treatment. These protective effects may be, at least in part, produced by the reduction of neuronally derived NO and peroxynitrite caused by MPTP. Our results also demonstrate that MPTP can cause functional damage of interneurons in the substantia nigra. These results suggest the possibility that nNOS inhibitors as well as MAO-B inhibitors may be therapeutically useful in neurodegenerative diseases such as Parkinson's disease. Thus our present results provide valuable information for the pathogenesis of degeneration of the nigrostriatal dopaminergic neuronal pathway.

キーワード 推奨
  1. (英) MPTP
  2. (英) Neuronal nitric oxide synthase (nNOS) inhibitor
  3. (英) Monoamine oxidase-B (MAO-B) inhibitor
  4. (英) Dopamine content
  5. 免疫組織化学(immunohistochemistry)
  6. (英) Mice
発行所 推奨 Elsevier(->組織[Elsevier Science])
誌名 必須 European Neuropsychopharmacology(European College of Neuropsychopharmacology)
(pISSN: 0924-977X, eISSN: 1873-7862)
ISSN 任意 0924-977X
ISSN: 0924-977X (pISSN: 0924-977X, eISSN: 1873-7862)
Title: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Title(ISO): Eur Neuropsychopharmacol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 14
必須 2
必須 93 104
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年月日 必須 2004年 3月 初日
URL 任意 http://dx.doi.org/10.1016/S0924-977X(03)00065-8
DOI 任意 10.1016/S0924-977X(03)00065-8    (→Scopusで検索)
PMID 任意 15013024    (→Scopusで検索)
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  1. (英) Article.Affiliation: Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't