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著作: [荒木 勉]/Mikami Tadayoshi/Tanji Hiroaki/Matsubara Mitsunobu/Imai Yutaka/Mizugaki Michinao/Itoyama Yasuto/Biochemical and immunohistological changes in the brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse/[European Journal of Pharmaceutical Sciences]

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134833
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2014年4月12日(土) 18:58:59
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大家 隆弘
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[学科長]/[徳島大学.薬学部.薬学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 荒木 勉
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Mikami Tadayoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Tanji Hiroaki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Matsubara Mitsunobu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Imai Yutaka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Mizugaki Michinao
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Itoyama Yasuto
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Biochemical and immunohistological changes in the brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse

副題 任意
要約 任意

(英) We investigated neurochemically and neuropathologically the utility of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice as a model of Parkinson's disease. The changes in dopamine D1 and D2 receptors and dopamine uptake sites were determined by quantitative autoradiography using [3H]SCH23390, [3H]raclopride and [3H]mazindol, respectively. Dopamine and 3,4-dihydroxyphenyl acetic acid (DOPAC) contents in the striatum were measured by high-performance liquid chromatography. The distribution of nigral neurons and reactive astrocytes was determined by immunohistochemical staining with antibody against tyrosine hydroxylase (TH) and glial fibrillary acidic protein (GFAP). The mice received four intraperitoneal injections of MPTP (10 mg/kg) at 1-h intervals and then the brains were analyzed at 3 and 7 days after the treatments. No significant change in dopamine D1 receptors was observed in the striatum and substantia nigra after acute treatment with MPTP. Dopamine D2 receptors were reduced significantly in the substantia nigra only 7 days after the MPTP treatment, whereas striatum showed no significant change in the binding throughout the experiments. In contrast, dopamine uptake sites were reduced markedly in the striatum and substantia nigra 3 and 7 days after the MPTP treatment. Dopamine and DOPAC content were also reduced in the striatum 3 and 7 days after the MPTP treatment. An immunohistochemical study indicated a loss of the number of TH-positive neurons in the substantia nigra 7 days after the MPTP treatment. In contrast, numerous GFAP-positive astrocytes were evident in the striatum 7 days after the MPTP treatment. These results provide valuable information for the pathogenesis of acute stage of Parkinson's disease.

キーワード 推奨
  1. (英) MPTP
  2. (英) Dopaminergic receptors
  3. (英) Dopamine uptake sites
  4. (英) Receptor autoradiography
  5. 免疫組織化学(immunohistochemistry)
  6. (英) Mouse
発行所 推奨 Elsevier Science B.V.
誌名 必須 European Journal of Pharmaceutical Sciences(European Federation for Pharmaceutical Sciences)
(pISSN: 0928-0987, eISSN: 1879-0720)
ISSN 任意 0928-0987
ISSN: 0928-0987 (pISSN: 0928-0987, eISSN: 1879-0720)
Title: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Title(ISO): Eur J Pharm Sci
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 12
必須 3
必須 231 238
都市 任意
年月日 必須 2001年 1月 初日
URL 任意 http://dx.doi.org/10.1016/S0928-0987(00)00170-6
DOI 任意 10.1016/S0928-0987(00)00170-6    (→Scopusで検索)
PMID 任意 11113642    (→Scopusで検索)
NAID 任意 80012304812
WOS 任意 000166248100008
Scopus 任意 2-s2.0-0033663904
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article