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著作: Kato Hiroyuki/Kogure Kyuya/[荒木 勉]/Liu Xiao-Hong/Kato Kanefusa/Itoyama Yasuto/Immunohistochemical localization of superoxide dismutase in the hippocampus following ischemia in a gerbil model of ischemic tolerance/[Journal of Cerebral Blood Flow and Metabolism]

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EID
134670
EOID
939122
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LastModified
2019年2月20日(水) 11:33:54
Operator
三木 ちひろ
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[学科長]/[徳島大学.薬学部.薬学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kato Hiroyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kogure Kyuya
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 荒木 勉
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Liu Xiao-Hong
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kato Kanefusa
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Itoyama Yasuto
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Immunohistochemical localization of superoxide dismutase in the hippocampus following ischemia in a gerbil model of ischemic tolerance

副題 任意
要約 任意

(英) Pretreatment of the gerbil brain with a 2-min period of sublethal ischemia protects against neuronal damage following a subsequent 3-min period of ischemia, which normally destroys pyramidal neurons in the CA1 region of the hippocampus. To clarify the role of superoxide dismutase (SOD) in this ischemic tolerance, we immunohistochemically investigated the alterations in copper-zinc SOD (CuZnSOD) and manganese SOD (Mn-SOD) in the gerbil hippocampus following 3-min ischemia with or without the first mild ischemia. Normal hippocampus showed an intense CuZnSOD immunostaining in pyramidal neurons but relatively less MnSOD immunostaining. MnSOD, but not CuZnSOD, immunoreactivity increased after the first ischemia. Both CuZnSOD and MnSOD immunoreactivities decreased throughout the hippocampus 4 h after 3 min of ischemia both with and without the first ischemia. The immunostaining recovered in resistant regions (CA3 and dentate gyrus) after 1 day in both groups and in the pretreated CA1 after 2 days. Without pretreatment, however, the immunostaining never recovered in the vulnerable CA1 region. The results suggest that ischemic tolerance is induced in part by enhanced synthesis of MnSOD in the tolerance-acquired hippocampus. Both CuZnSOD and MnSOD immunoreactivities decreased after the second ischemia even in the pretreated hippocampus in the early reperfusion periods, but ischemic tolerance facilitated the recovery from the postischemic reductions in SOD immunoreactivity.

キーワード 推奨
  1. (英) Animals
  2. (英) Gerbillinae
  3. (英) Hippocampus
  4. 免疫組織化学(immunohistochemistry)
  5. (英) Ischemic Attack, Transient
  6. (英) Kinetics
  7. (英) Male
  8. (英) Manganese
  9. (英) Neuroglia
  10. (英) Reperfusion
  11. (英) Superoxide Dismutase
発行所 推奨
誌名 必須 Journal of Cerebral Blood Flow and Metabolism(International Society of Cerebral Blood Flow and Metabolism)
(pISSN: 0271-678X, eISSN: 1559-7016)
ISSN 任意 0271-678X
ISSN: 0271-678X (pISSN: 0271-678X, eISSN: 1559-7016)
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Title(ISO): J Cereb Blood Flow Metab
Publisher: SAGE Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 15
必須 1
必須 60 70
都市 任意
年月日 必須 1995年 1月 初日
URL 任意
DOI 任意 10.1038/jcbfm.1995.7    (→Scopusで検索)
PMID 任意 7798339    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article

  2. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't