著作: [堀部 ますみ]/Sawa Takamasa/[片岡 正俊]/[木戸 淳一]/[永田 俊彦]/Regulation of tenascin expression in cultured rat dental pulp cells/[Odontology]
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削除する| 種別 | 必須 | 学術論文(審査論文) | |||
|---|---|---|---|---|---|
| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | ||||
| カテゴリ | 推奨 | ||||
| 共著種別 | 推奨 | ||||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 | ||||
| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) Regulation of tenascin expression in cultured rat dental pulp cells |
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| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) Tenascin (TN) is a glycoprotein of extracellular matrix abundantly present in embryonic mesenchymal tissues. Transforming growth factor-beta1 (TGF-beta1), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), hepatocyte growth factor (HGF), and retinoic acid (RA) are important regulators of dentinogenesis. Dental pulp cells have the capacity to differentiate into odontoblast-like cells. In this study, we investigated the effects of growth factors on TN expression and adhesive function using rat clonal dental pulp cells, RPC-C2A. Analyses of reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting revealed that RPC-C2A cells expressed TN molecules and that TGF-beta1, HGF, and RA increased expression of TN at the mRNA and protein level, while bFGF and EGF showed a weak effect. An adhesion assay revealed that treatment with TGF-beta1, HGF, and RA induced a marked reduction of cell attachment to fibronectin (FN)-coated surfaces, whereas there was no change with bFGF and EGF. Functional blocking of growth factor-stimulated TN protein by pretreating cells with anti-TN antibodies restored cell attachment to control levels. These findings suggest that TGF-beta1, HGF, and RA may regulate pulpal cell adhesion to FN-coated surfaces and that this effect is mediated by TN. |
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| キーワード | 推奨 |
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| 発行所 | 推奨 | Springer-Verlag | |||
| 誌名 | 必須 |
Odontology(日本歯科大学歯学会)
(pISSN: 1618-1247, eISSN: 1618-1255)
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| 巻 | 必須 | 92 | |||
| 号 | 必須 | 1 | |||
| 頁 | 必須 | 22 26 | |||
| 都市 | 任意 | 東京(Tokyo/[日本国]) | |||
| 年月日 | 必須 | 2004年 9月 初日 | |||
| URL | 任意 | http://www.springerlink.com/link.asp?id=vb5uyxfy2hkcvnkf | |||
| DOI | 任意 | 10.1007/s10266-004-0038-1 (→Scopusで検索) | |||
| PMID | 任意 | 15490301 (→Scopusで検索) | |||
| CRID | 任意 | ||||
| WOS | 任意 | ||||
| Scopus | 任意 | ||||
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| 指導教員 | 推奨 | ||||
| 備考 | 任意 |
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