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著作: Shimizu Yasuki/[片岡 正俊]/[瀬戸 浩行]/[木戸 淳一]/[永田 俊彦]/Nifedipine induces gingival epithelial hyperplasia in rats through inhibition of apoptosis/[Journal of Periodontology]

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EID
134547
EOID
689648
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2013年6月5日(水) 16:29:45
Operator
大家 隆弘
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永田 俊彦
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
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著者 必須
  1. (英) Shimizu Yasuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 片岡 正俊
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 瀬戸 浩行
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 木戸 淳一([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 永田 俊彦
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Nifedipine induces gingival epithelial hyperplasia in rats through inhibition of apoptosis

副題 任意
要約 任意

(英) Nifedipine is used as a long-acting vasodilator; one of its side effects is gingival overgrowth, characterized by an accumulation of collagenous components within the gingival connective tissue and epithelial hyperplasia with elongated, branched rete pegs penetrating into the connective tissue. We investigated the effect of nifedipine on apoptosis of gingival keratinocytes of rats to elucidate the mechanism of nifedipine-induced gingival epithelial hyperplasia. Twenty-day-old rats were fed a powdered diet containing or lacking nifedipine for 8 to 30 days. The mandibular gingiva and palatal mucosa were removed on days 8, 15, or 30, and epithelial thickness was examined by light microscopy. In situ terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay was used to examine apoptosis of keratinocytes in the epithelium. In addition, we examined the effects of nifedipine on proliferation of keratinocytes and epithelial cell life on day 8 by 5-bromo-2'-deoxyuridine (BrdU) staining. Microscopic examination showed gingival epithelial hyperplasia in nifedipine-treated rats after day 15. Apoptosis of gingival keratinocytes was seen to be inhibited in nifedipine-treated rats on day 8 and 15. Also, nifedipine did not induce an increase of keratinocyte proliferation activity in terms of the number of cells showing positive staining with BrdU. Prolongation of cell life by nifedipine was observed on day 8 in gingival epithelium through a delay of upward cell movement compared to controls. However, epithelial hyperplasia was not detected in palatal mucosa, and there were no significant differences in apoptotic rates of keratinocytes and cell life between nifedipine-treated rats and control rats. These results suggest that nifedipine induces epithelial hyperplasia in gingival overgrowth not by an increase in keratinocyte proliferation, but by prolongation of cell life through reduction of apoptosis before epithelial hyperplasia is detectable.

キーワード 推奨
  1. (英) animal studies
  2. (英) nifedipine/adverse effects
  3. (英) gingibal hyperplasia/physiology
  4. (英) cell survival
  5. アポトーシス(apoptosis)
  6. (英) gingival overgrowth
発行所 推奨
誌名 必須 Journal of Periodontology(American Academy of Periodontology)
(pISSN: 0022-3492, eISSN: 1943-3670)
ISSN 任意 0022-3492
ISSN: 0022-3492 (pISSN: 0022-3492, eISSN: 1943-3670)
Title: Journal of periodontology
Title(ISO): J Periodontol
Supplier: American Academy of Periodontology
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef  (CrossRef (Scopus information is found. [need login])
必須 73
必須 8
必須 861 867
都市 任意
年月日 必須 2002年 8月 初日
URL 任意 http://www.joponline.org/doi/abs/10.1902/jop.2002.73.8.861
DOI 任意 10.1902/jop.2002.73.8.861    (→Scopusで検索)
PMID 任意 12211494    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Periodontology and Endodontology, Tokushima University School of Dentistry, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't