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著作: Akio Iuchi/[中堀 豊]/Boki Keito/Uptake of Heterocyclic Aromatic Amine by Insoluble Dietary Fiber in Artificial Gastric and Intestinal Juice/[Environmental Health and Preventive Medicine]

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EID
134483
EOID
732355
Map
0
LastModified
2014年5月1日(木) 11:16:19
Operator
松井 栄里
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TRUE
Censor
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Owner
[副研究部長]/[大学院ヘルスバイオサイエンス研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Akio Iuchi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 中堀 豊
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Boki Keito
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Uptake of Heterocyclic Aromatic Amine by Insoluble Dietary Fiber in Artificial Gastric and Intestinal Juice

副題 任意
要約 任意

(英) The purpose of the presentin vitro study was to predict to what extent dietary fiber (DF) takes up heterocyclic aromatic amine (HAA) and how DF acts to intercept HAAsin vivo. The sorption isotherms of 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline (MeIQ), 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole acetate (Trp-P-1), and 3-amino-1-methyl-5H-pyrido[4,3-b]indole acetate (Trp-P-2) for DF were measured in artificial intestinal juice (AIJ) and artificial gastric juice (AGJ) at 37°C. The desorption of HAA from DF was measured in AGJ and AIJ. The sorption isotherms were statistically classified into four types. The percentage of Trp-Ps taken up by carboxymethylated cellulose (CMC) and agar in AGJ (pH, 1.2) was 52-56% and 58-78%, respectively. On the other hand, the percentage of Trp-Ps taken up by CMC and agar in AIJ (pH, 6.8) was 97-98% and 87-89%, respectively. The percentage of IQ and MeIQ sorbed by CMC was 21-27% in AGJ and 100% in AIJ. Collagen and chitin did not remove any HAAs in AGJ, but removed 4-69% in AIJ. In the four-component solution, the percentage of HAA taken up by DF was almost the same or significantly increased, with a few exceptions, as compared with that in the one-component solution. The results indicated that MeIQ is mainly held on the surface of CMC in AIJ, and that Trp-P-1 and Trp-P-2 are mainly held in the interior of agar in AGJ and AIJ. The results on sorption-desorptionin vitro indicate that sorbed HAAs in the stomach are held more firmly by agar than by CMC while DF passes through the human intestinal tract. CMC and agar would be expected to be more useful than collagen and chitin as agents intercepting HAAs.

キーワード 推奨
  1. (英) Dietary Fiber
  2. (英) Heterocyclic Aromatic Amine
  3. (英) Type of Sorption Isotherm
  4. (英) Sorption Mechanism
  5. (英) Amount Sorbed
発行所 推奨
誌名 必須 Environmental Health and Preventive Medicine(日本衛生学会)
(pISSN: 1342-078X, eISSN: 1347-4715)
ISSN 任意 1342-078X
ISSN: 1342-078X (pISSN: 1342-078X, eISSN: 1347-4715)
Title: Environmental health and preventive medicine
Title(ISO): Environ Health Prev Med
Supplier: 日本衛生学会
Publisher: Springer Japan
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 9
必須 2
必須 47 52
都市 任意
年月日 必須 2004年 3月 初日
URL 任意
DOI 任意 10.1007/BF02897931    (→Scopusで検索)
PMID 任意 21432298    (→Scopusで検索)
NAID 任意 110002663956
WOS 任意
Scopus 任意 2-s2.0-1842786505
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1007/BF02897931

  2. (英) Article.Affiliation: Department of Human Genetics and Public Health, Graduate School of Proteomics, The University of Tokushima, Kuramoto-cho, 770-8503, Tokushima, Japan.

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) OtherID: PMC2723392