著作: [細川 義隆]/[中西 正]/[山口 大輔]/[中江 英明]/[松尾 敬志]/Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in periodontal diseased tissue/[Clinical and Experimental Immunology]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in periodontal diseased tissue |
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副題 | 任意 | ||||
要約 | 任意 |
(英) The regulatory role of chemokines and chemokine receptors on specific leucocyte recruitment into periodontal diseased tissue is poorly characterized. We observed that leucocytes infiltrating inflamed gingival tissue expressed marked levels of CX3CR1. In periodontal diseased tissue, the expression of fractalkine and CX3CR1 mRNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) and further, fractalkine was distributed mainly on endothelial cells, as shown by immunohistochemistry. Moreover, we can detect CX3CR1-expressing cells infiltrated in periodontal diseased tissue by immunohistochemical staining. Furthermore, fractalkine production by human umbilical vein endothelial cells (HUVEC) was up-regulated by pathogen-associated molecular patterns (PAMPs), including Porphyromonas gingivalis lipopolysaccharide (LPS). Thus, these findings suggested that CX3CR1 and the corresponding chemokine, fractalkine may have an important regulatory role on specific leucocyte migration into inflamed periodontal tissue. |
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キーワード | 推奨 |
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発行所 | 推奨 | ||||
誌名 | 必須 |
Clinical and Experimental Immunology(British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)
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巻 | 必須 | 139 | |||
号 | 必須 | 3 | |||
頁 | 必須 | 506 512 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2005年 3月 初日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.1111/j.1365-2249.2005.02675.x (→Scopusで検索) | |||
PMID | 任意 | 15730397 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | 000227226900016 | |||
Scopus | 任意 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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