徳島大学 教育・研究者情報データベース(EDB)

1. (英) Tani Hideki / (日) 谷 英紀 / (読) たに ひでき

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2. 内藤 毅

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3. 塩田 洋

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4. (英) Mimura Yasuo / (日) 三村 康男 / (読) みむら やすお

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(英) A Study of Acute Infection of Herpes Simplex Virus in Mouse Trigeminal Ganglia

(日) マウス三叉神経節における単純ヘルペスウイルスの急性感染の検討

(英) We investigated the shift to latency and protective reaction in mice trigeminal ganglia after inoculation of herpes simplex virus type 1 (HSV-1) onto the cornea. BALB/c mice were inoculated and the trigeminal ganglia were removed periodically. Lymphocytes in the ganglia were observed using immunocytochemical techniques. The results obtained were as follows: (1) HSV-1 positive neuronal cells were recognized at 3 days after inoculation but not at 14 days. (2) The relative proportion of T cells in lymphocytes was greater than that of B cells at 3 days, but B cells were more numerous at 5 days. Then T cells become more numerous again at 7 days. (3) Among the subsets in T cells, the ratio of CD4+ and CD8+ cells was almost equal at 3 days, but then CD4+ cells increased and CD8+ cells had disappeared at 14 days after inoculation. These results show that HSV-1 that reached the trigeminal ganglion from the cornea by axonal transport infected neuronal cells, multiplied there and then disappeared resulting in latency. Cellular immunity, especially the function of CD4+ cells, played a main role in this protective reaction by suppressing the viral growth.

1. (英) HSV-1 / (日) 単純ヘルペスウイルス1型 / (読) たんじゅんへるぺすういるす
2. (英) Trigeminal ganglion / (日) 三叉神経節
3. (英) CD4+ cells / (日) CD4陽性細胞
4. (英) CD8+ cells / (日) CD8陽性細胞

1. 2-s2.0-0029837469

1. (英) Article.PublicationTypeList.PublicationType: English Abstract

2. (英) Article.PublicationTypeList.PublicationType: Journal Article