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著作: Katunuma Nobuhiko/[塩田 洋]/Le Quang Trong/Medical significance of cysteine protease inhibitors in mammalian secretory fluids/[The Journal of Medical Investigation : JMI]

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878390
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2017年12月4日(月) 14:07:04
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[学科長]/[徳島大学.医学部.医学科]
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種別 必須 総説·解説
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
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著者 必須
  1. (英) Katunuma Nobuhiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 塩田 洋
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Le Quang Trong
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Medical significance of cysteine protease inhibitors in mammalian secretory fluids

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(英) New cysteine protease inhibitors in human tears and milk and their medical significance are reviewed in this paper. As protective components against bacterial infection in the eyes, we detected four kinds of anti-bacterial proteins in normal human tears including lysozyme and three kinds of cysteine protease inhibitors. Using our reverse zymography of normal tears, three kinds of cysteine protease inhibitors were found to be 78kDa, 20kDa and 15kDa and were determined to be lactoferrin, Von Ebner's Gland (VEG) protein and cystatin S, respectively. All of them belong to the cystatin super family and VEG protein and cystatin S are well known cysteine protease inhibitors. The C-terminus area 17mer peptide, Y679-K695, of lactoferrin showed strong homology with a common active domain of the cystatin family and the synthesized peptide showed inhibition of cysteine proteases. Not only were disease-specific changes found in these inhibitor profiles, but also disease-specific new inhibitors in patients tears with certain autoimmune diseases. A 35kDa inhibitor, which was detected specifically in tears with Behcet's disease, an typical autoimmune disease, was determined to be a lacrimal acidic proline-rich protein based on the N-terminus sequence analysis. A 65kDa inhibitor of tears with Harada's autoimmune disease was determined to be an Ig heavy chain V-III region. In addition, lactoferrin content in Harada's disease was very low. We found two cathepsin inhibitors in bovine milk using reverse zymography, namely lactoferrin and beta-casein. The L133-Q151, in the human beta-casein molecule is the active inhibitory domain. They may play an important role in antiseptic and anti-infectious functions.

キーワード 推奨
  1. (英) cysteine protease inhibitor
  2. (英) human tears
  3. (英) reverse zymography
  4. (英) Behcet's disease
  5. (英) lactoferrin
  6. (英) milk
  7. (英) autoimmune diseases
発行所 推奨 (英) University of Tokushima School of Medicine
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: University of Tokushima
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 50
必須 3-4
必須 154 161
都市 任意
年月日 必須 2003年 8月 初日
URL 任意
DOI 任意
PMID 任意 13678384    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
機関リポジトリ 110691
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被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article

  2. (英) Article.PublicationTypeList.PublicationType: Review

  3. (英) NumberOfReferences: 22