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著作: Sogawa Ken-ichi/[近藤 和也]/Fujino Haruhiko/Takahashi Yuji/[三好 孝典]/[先山 正二]/Mukai Kiyoshi/Monden Yasumasa/Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors/[Cancer]

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EID
132326
EOID
691151
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LastModified
2013年6月16日(日) 19:56:09
Operator
大家 隆弘
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近藤 和也
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
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著者 必須
  1. (英) Sogawa Ken-ichi
    役割 任意
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    学籍番号 推奨
  2. 近藤 和也([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.臨床腫瘍医療学]/[徳島大学.医学部.保健学科.看護学専攻.成人·高齢者看護学講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Fujino Haruhiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Takahashi Yuji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 三好 孝典
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 先山 正二
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    貢献度 任意
    学籍番号 推奨
  7. (英) Mukai Kiyoshi
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    貢献度 任意
    学籍番号 推奨
  8. (英) Monden Yasumasa
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors

副題 任意
要約 任意

(英) A distinction between noninvasive, invasive, and metastatic thymoma on the basis of the cytologic features is difficult. The current study investigated whether the expression of MMP and TIMP was correlated with tumor invasiveness and prognosis in patients with thymoma. Tumor tissue samples were obtained from 42 patients with thymic epithelial tumors between 1974 and 2001 at Tokushima University Hospital. Three-micrometer-thick, formalin-fixed, paraffin-embedded tissue sections were immunostained using specific antibodies against MMP-2, MMP-9, TIMP-1, and TIMP-2. MMP-2 expression was detected in 30 tumors (71%), and TIMP-2 expression was detected in 31 tumors (74%). MMP-9 expression was detected in 22 of 36 tumors (61%), and TIMP-1 expression was detected in only 7 tumors (19%). MMP-2 and TIMP-2 expression levels were very low (10% and 0%, respectively) in noninvasive tumors but were very high (91% and 97%, respectively) in invasive tumors. In thymic epithelial tumors, the more progressive the clinical stage of tumor, the higher the strongly positive rate of MMP-2 and TIMP-2 expression. There was no correlation between positivity for MMP-9 and stage. Twenty-five percent of Type AB thymomas and 50% of Type B1 thymomas expressed MMP-2 and TIMP-2. Most of Type A, Type B2, Type B3, and Type C thymomas expressed MMP-2 and TIMP-2. There were significant differences in disease-free survival at 5 years between patients without and with MMP-2 expression (91% vs. 55%, respectively) and patients without and with TIMP-2 expression (100% vs. 53%, respectively). MMP-2 and TIMP-2 are key enzymes for invasiveness of thymic epithelial tumors. The expression of these proteins can predict a poor outcome in patients with thymoma.

キーワード 推奨
  1. (英) thymoma
  2. (英) matrix metalloproteinase
  3. (英) tissue inhibitor of metalloproteinase
  4. (英) invasiveness
  5. 免疫組織化学(immunohistochemistry)
発行所 推奨 (英) American Cancer Society
誌名 必須 Cancer(American Cancer Society)
(pISSN: 0008-543X, eISSN: 1097-0142)
ISSN 任意 0008-543X
ISSN: 0008-543X (pISSN: 0008-543X, eISSN: 1097-0142)
Title: Cancer
Title(ISO): Cancer
Supplier: American Cancer Society
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 98
必須 9
必須 1811 1821
都市 任意
年月日 必須 2003年 9月 26日
URL 任意
DOI 任意 10.1002/cncr.11725    (→Scopusで検索)
PMID 任意 14584061    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article