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著作: Harashima H/Komatsu S/Kojima H/Yanagi C/Morioka Y/Naito M/[際田 弘志]/Species difference in the disposition of liposomes among mice, rats, and rabbits: Allometric relationship and species dependent hepatic uptake mechanism/[Pharmaceutical Research]

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131055
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2018年12月3日(月) 14:27:12
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大家 隆弘
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[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Harashima H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Komatsu S
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Kojima H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Yanagi C
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Morioka Y
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Naito M
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 際田 弘志
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Species difference in the disposition of liposomes among mice, rats, and rabbits: Allometric relationship and species dependent hepatic uptake mechanism

副題 任意
要約 任意

(英) The species difference in the pharmacokinetics of liposomes was investigated in mice, rats and rabbits. Liposomes were intravenously injected at doses of 1, 10 and 100 (nmol/g body weight), and the time courses of liposomes in blood, liver and spleen were measured. Pharmacokinetic parameters were regressed as a function of body weight (BW) and dose of liposomes (D). The uptake mechanism of liposomes was also examined with the isolated perfused liver between rats and mice. Mean residence time increased with the increase of BW and D of liposomes. This increase of mean residence time resulted from the decreased total body clearance, which was principally explained by the species difference in the hepatic uptake clearance (CLh) of liposomes. The parameter CLh was regressed well by a multiple regression as a function of BW and D. In this analysis, an exponent for BW was around 0.5, which clearly indicates that smaller animals have higher uptake clearance per unit BW. Immunohistochemical analysis revealed that there was no significant difference in the density of Kupffer cells among these species. This suggest that the species difference in CLh resulted not from the density of Kupffer cells but from the uptake ability of Kupffer cells among species. In the isolated perfused liver, the hepatic uptake of liposomes was mainly explained by opsonin dependent uptake in rats, while opsonin independent uptake in mice. These quantitative and qualitative information on the species difference of liposome disposition will provide an useful information for constructing a drug delivery system using liposomes.

キーワード 推奨
  1. (英) Animals
  2. (英) Body Weight
  3. (英) Dose-Response Relationship, Drug
  4. 免疫組織化学(immunohistochemistry)
  5. (英) In Vitro Techniques
  6. (英) Kupffer Cells
  7. リポソーム(liposomes)
  8. (英) Liver
  9. (英) Mice
  10. (英) Opsonin Proteins
  11. (英) Rabbits
  12. (英) Rats
  13. (英) Rats, Wistar
  14. (英) Species Specificity
  15. (英) Spleen
発行所 推奨
誌名 必須 Pharmaceutical Research(American Association of Pharmaceutical Scientists)
(pISSN: 0724-8741, eISSN: 1573-904X)
ISSN 任意 0724-8741
ISSN: 0724-8741 (pISSN: 0724-8741, eISSN: 1573-904X)
Title: Pharmaceutical research
Title(ISO): Pharm Res
Supplier: Kluwer Online
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 13
必須 7
必須 1049 1054
都市 任意
年月日 必須 1996年 7月 初日
URL 任意
DOI 任意 10.1023/A:1016058724452    (→Scopusで検索)
PMID 任意 8842043    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-0029739890
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article

  2. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't