著作: [羽地 達次]/Association of protein phosphatase 1 delta with nucleolin in osteoblastic cells and cleavage of nucleolin in apoptosis-induced osteoblastic cells/[Acta Histochemica et Cytochemica]
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| 種別 | 必須 | 学術論文(審査論文) | |||||||||
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| 言語 | 必須 | 英語 | |||||||||
| 招待 | 推奨 | ||||||||||
| 審査 | 推奨 | Peer Review | |||||||||
| カテゴリ | 推奨 | 研究 | |||||||||
| 共著種別 | 推奨 | ||||||||||
| 学究種別 | 推奨 | ||||||||||
| 組織 | 推奨 |
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| 著者 | 必須 |
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| 題名 | 必須 |
(英) Association of protein phosphatase 1 delta with nucleolin in osteoblastic cells and cleavage of nucleolin in apoptosis-induced osteoblastic cells |
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| 副題 | 任意 | ||||||||||
| 要約 | 任意 |
(英) Protein phosphorylation and dephosphorylation has been recognized as a key mechanism in cell function. Okadaic acid is a potent inhibitor of PP1 and PP 2A and induces apoptosis in human or mouse cells including osteoblasts. Nucleolin is an abundantly expressed nucleolar phosphoprotein and is located mainly in the nucleolus. The staining pattern of nucleolin in cultured osteoblastic cells is similar to that of PP1δ. Nucleolin was demonstrated to bind to PP1δ in nucleolus in human osteoblastic cells by using immunocytochemical and immunoprecipitation methods. AgNORs and nucleolin, visible as dots in the nuclei of the control osteoblastic cells, disappeared from the nuclei of the osteoblastic cells treated with okadaic acid. A major band, 110 kDa, was detected in the proteins obtained from osteoblastic cells. The level of the 110 kDa protein decreased in the apoptotic osteoblastic cells, whereas an additional band, 80 kDa, appeared and the level of this protein increased in the proteins prepared from okadaic acid-induced apoptotic osteoblastic cells. Our results indicate that PP1δ directly binds to nucleolin in the nucleolus of osteoblastic cells and that nucleolin is cleaved during apoptosis in osteoblastic cells. |
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| キーワード | 推奨 |
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| 発行所 | 推奨 | (英) Japan Society of Histochemistry and Cytochemistry (JSHC) / (日) 日本組織細胞化学会 | |||||||||
| 誌名 | 必須 |
Acta Histochemica et Cytochemica(日本組織細胞化学会)
(pISSN: 0044-5991, eISSN: 1347-5800)
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| 巻 | 必須 | 38 | |||||||||
| 号 | 必須 | 1 | |||||||||
| 頁 | 必須 | 1 8 | |||||||||
| 都市 | 任意 | ||||||||||
| 年月日 | 必須 | 2005年 1月 1日 | |||||||||
| URL | 任意 | http://ci.nii.ac.jp/naid/110003161222/ | |||||||||
| DOI | 任意 | 10.1267/ahc.38.1 (→Scopusで検索) | |||||||||
| PMID | 任意 | ||||||||||
| CRID | 任意 | 1390282679839200768 | |||||||||
| NAID | 110003161222 | ||||||||||
| WOS | 任意 | 000228366600001 | |||||||||
| Scopus | 任意 | 2-s2.0-17644394184 | |||||||||
| 評価値 | 任意 | ||||||||||
| 被引用数 | 任意 | ||||||||||
| 指導教員 | 推奨 | ||||||||||
| 備考 | 任意 | ||||||||||