徳島大学 教育・研究者情報データベース(EDB)

1. 澤田 和彦

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   貢献度	任意
   学籍番号	推奨

2. 福井 義浩

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(英) Expression of tyrosine hydroxylase in cerebellar Purkinje cells of ataxic mutant mice:its relation to the onset and/or development of ataxia

(英) This report describes recent studies on tyrosine hydroxylase (TH) expression in Purkinje cells of the cerebellum of ataxic mutant mice. An increased expression of TH in some Purkinje cells has been observed in two allelic groups of mutant mice, tottering and dilute. TH-positive Purkinje cells appeared preceding the onset of ataxia. Northern blot analysis revealed 2.1 kb of TH mRNA in the mutant cerebella, and the size was identical to that of TH transcripts in other brain regions. However, TH in Purkinje cells did not seem to participate in catecholamine biosynthesis. In vitro studies showed that cultured non-catecholaminergic neurons expressed the TH transcripts following Ca2+ influx. Therefore, abnormal TH expression in the mutant Purkinje cells may indicate neuronal dysfunction caused by misregulation of intracellular Ca2+ concentrations.

1. (英) Purkinje cells
2. (英) ataxia
3. (英) tyrosine hydroxylase
4. (英) calcium channel
5. (英) tottering
6. (英) rolling mouse Nagoya
7. (英) dilute-lethal mouse

1. (英) Article.PublicationTypeList.PublicationType: Journal Article

2. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't