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著作: Koyama A Hajime/[足立 昭夫]/Irie Hiroshi/Physiological significance of apoptosis during animal virus infection/[International Reviews of Immunology]

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EID
130187
EOID
890857
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LastModified
2018年3月2日(金) 15:44:10
Operator
三木 ちひろ
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[副研究部長]/[徳島大学.大学院医歯薬学研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Koyama A Hajime
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 足立 昭夫
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Irie Hiroshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Physiological significance of apoptosis during animal virus infection
副題 任意
要約 任意

(英) Apoptosis has been considered to be a host defense mechanism against viral infection in multicellular organisms. This is based on the findings that apoptogenic mutants of insect viruses cannot grow because infected host cells die by apoptosis. This suggests that the apoptotic response of host cells has a deleterious effect on virus infection. Thus, apoptosis is an important host defense mechanism that is capable of inhibiting viral replication during infection. However, in vitro studies indicated that apoptosis alone does not provide the same protection against viral infection in animal cells as it does in the insect cells. Still, most animal viruses have acquired a strategy to overcome host cell apoptosis. In addition, a varying degree of necrosis usually accompanies apoptosis, suggesting a possible contribution of necrosis to the host reactions against virus. To understand the physiological significance of apoptosis during animal virus infection, we have characterized viral growth and the cellular responses against virus infection in a wide variety of virus-cell interaction systems. Mainly based on our own works, we discuss the nature of apoptosis in the animal virus infection and verify its role as a host defense mechanism against virus infection.
キーワード 推奨
  1. (英) Animals
  2. アポトーシス(apoptosis)
  3. 細胞質分裂(cytokinesis)
  4. (英) Host-Parasite Interactions
  5. (英) Necrosis
  6. (英) Virus Diseases
  7. (英) Virus Physiological Phenomena
  8. (英) Virus Replication
発行所 推奨
誌名 必須 International Reviews of Immunology(Informa Healthcare)
(pISSN: 0883-0185, eISSN: 1563-5244)
ISSN 任意 0883-0185
ISSN: 0883-0185 (pISSN: 0883-0185, eISSN: 1563-5244)
Title: International reviews of immunology
Title(ISO): Int Rev Immunol
Publisher: Taylor & Francis
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
巻 必須 22
号 必須 5-6
頁 必須 341 359
都市 任意
年月日 必須 2003年 9月 初日
URL 任意 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12959749&dopt=Abstract
DOI 任意 10.1080/08830180305210    (→Scopusで検索)
PMID 任意 12959749    (→Scopusで検索)
CRID 任意
WOS 任意 000220165100003
Scopus 任意 2-s2.0-0141997748
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意

  1. (英) Article.Affiliation: Department of Virology, The University of Tokushima Graduate School of Medicine, Tokushima 770-8503, Japan. koyama@basic.med.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) Article.PublicationTypeList.PublicationType: Review

  5. (英) MedlineDate: 2003 Sep-Dec

  6. (英) NumberOfReferences: 71