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著作: Hagiwara Mari/[片岡 佳子]/[有持 秀喜]/[桑原 知巳]/[大西 克成]/Role of unbalanced growth of Gram-negative bacteria in ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug/[The Journal of Medical Investigation : JMI]

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EID
128056
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片岡 佳子
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
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著者 必須
  1. (英) Hagiwara Mari
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  2. 片岡 佳子([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.微生物・遺伝子解析学])
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  3. 有持 秀喜([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
    役割 任意
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    学籍番号 推奨
  4. 桑原 知巳
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  5. 大西 克成
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題名 必須

(英) Role of unbalanced growth of Gram-negative bacteria in ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug

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(英) Nonsteroidal anti-inflammatory drugs (NSAIDs) induced formation of intestinal ulcers as side effects, in which an unbalanced increase in the number of gram-negative bacteria in the small intestine plays an important role. To clarify how intestinal microflora are influenced by NSAIDs, we examined the effects of 5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl) thiophene (BFMeT), an NSAID, on intestinal motility and on the growth of Escherichia coli and Lactobacillus acidophilus. Transit index, a marker of peristalsis, was not different in BFMeT-treated and solvent-treated rats, indicating that BFMeT increased the number of gram-negative bacteria without suppression of peristalsis. The factors that affect the growth of intestinal bacteria were not found in intestinal contents of BFMeT-treated rats, because the growth of E. coli and that of L. acidophilus in the supernatants of small intestinal contents of BFMeT-treated rats and solvent-treated rats were not different. The mechanism of the increase in the number of gram-negative bacteria is still unclear, but heat-killed E. coli cells and their purified lipopolysaccharide (LPS) caused deterioration of BFMeT-induced ileal ulcers, while they could not cause the ulcers by themselves without the NSAID. Concentration of LPS and myeloperoxidase activity level were elevated correlatively in the intestinal mucosa of rats treated with LPS and BFMeT. These results suggest that an increase in the number of gram-negative bacteria and their LPS in the mucosa induces activation of neutrophils together with the help of NSAID action and causes ulcer formation.

キーワード 推奨
  1. (英) nonsteroidal anti-inflammatory drugs (NSAIDs)
  2. (英) ulcer formation
  3. (英) lipopolysaccharide (LPS)
  4. (英) Escherichia coli
  5. (英) myeloperoxidase (MPO)
発行所 推奨 徳島大学.医学部
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 51
必須 1,2
必須 43 51
都市 任意
年月日 必須 2004年 2月 初日
URL 任意
DOI 任意 10.2152/jmi.51.43    (→Scopusで検索)
PMID 任意 15000255    (→Scopusで検索)
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機関リポジトリ 110713
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  1. (英) Article.Affiliation: Department of Molecular Bacteriology, Graduate School of Medicine, The University of Tokushima, Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't