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著作: Chiampanichayakul Sawitree/[片岡 佳子]/[有持 秀喜]/Thumvijit Somsakul/[桑原 知巳]/[中山 治之]/Vinitketkumnuen Usanee/Ohnishia Yoshinari/Inhibitory effects of bitter melon (Momordica charantia Linn.) on bacterial mutagenesis and aberrant crypt focus formation in the rat colon/[The Journal of Medical Investigation : JMI]

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2017年12月4日(月) 13:54:57
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片岡 佳子
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
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学究種別 推奨
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著者 必須
  1. (英) Chiampanichayakul Sawitree
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  2. 片岡 佳子([徳島大学.大学院医歯薬学研究部.保健科学域.保健科学部門.医用検査学系.微生物・遺伝子解析学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 有持 秀喜([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Thumvijit Somsakul
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    貢献度 任意
    学籍番号 推奨
  5. 桑原 知巳
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 中山 治之
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Vinitketkumnuen Usanee
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Ohnishia Yoshinari
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Inhibitory effects of bitter melon (Momordica charantia Linn.) on bacterial mutagenesis and aberrant crypt focus formation in the rat colon

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要約 任意

(英) Antimutagenicity and chemopreventive activity of an 80%-ethanol extract of bitter melon (Momordica charantia Linn.) against the formation of azoxymethane (AOM)-induced aberrant crypt foci (ACF) was investigated. The bitter melon extract was nonmutagenic and inhibited the mutagenicity of heterocyclic amines 2-amino-3,4-dimethylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and aflatoxin B1 in the Salmonella mutation assay. To examine the inhibitory effect of bitter melon on AOM-induced ACF formation, male F344 rats were fed various concentrations of the extract (0.1, 0.5, and 1.0 g/kg body weight) for five weeks during the initiation stage. One week after the administration of the plant extract, rats were subcutaneously given AOM at 15 mg/kg body weight once a week for two weeks. Three rats in each group were sacrificed 12 hr after the second AOM injection to analyze DNA adducts, O6-methylguanine (O6-meG) and N7-methylguanine in the liver and colon. The remaining rats were sacrificed 3 weeks after the second AOM injection to observe ACF. To examine the inhibitory effect of the extract on ACF formation in the postinitiation stage, rats were fed the extract at 0.1 and 1.0 g/kg body weight for 12 weeks starting two weeks after the second AOM injection. Treatment with bitter melon extract significantly inhibited ACF formation in the colon during the initiation stage and dose-dependently decreased the average of O6-meG DNA adduct in the colonic mucosa. During the postinitiation stage, bitter melon extract, at 1.0 g/kg body weight, significantly inhibited ACF formation in the colon, especially the formation of ACF with four or more crypts per focus. These findings suggest that bitter melon is a possible chemopreventive agent against colon carcinogenesis.

キーワード 推奨
  1. (英) bitter melon
  2. (英) Momordica charantia Linn
  3. (英) antimutagenicity
  4. (英) azoxymethane-induced aberrant crypt foci
  5. (英) O6-methylguanine
発行所 推奨 徳島大学.医学部
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 48
必須 1,2
必須 88 96
都市 任意
年月日 必須 2001年 2月 初日
URL 任意
DOI 任意
PMID 任意 11286022    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
機関リポジトリ 29051
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被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article

  2. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't