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著作: Yesilada Erdem/Deliorman Didem/Ergun Fatma/[高石 喜久]/Ono Yukihisa/Effects of the Turkish subspecies of Viscum album on macrophage-derived cytokines/[Journal of Ethnopharmacology]

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EID
127174
EOID
799486
Map
0
LastModified
2015年9月23日(水) 19:55:08
Operator
大家 隆弘
Avail
TRUE
Censor
承認済
Owner
高石 喜久
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Yesilada Erdem
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Deliorman Didem
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Ergun Fatma
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 高石 喜久([徳島大学.デザイン型AI教育研究センター])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Ono Yukihisa
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Effects of the Turkish subspecies of Viscum album on macrophage-derived cytokines

副題 任意
要約 任意

(英) Viscum album L. herbs are used for the treatment of various diseases. Apart from their immunostimulatory, antitumor, and hypotension inducing activities, anti-inflammatory effects has also been recorded in the literature. Since the immunostimulatory activity of mistletoe is mainly attributed to a stimulation of the mononuclear phagocytic system and to an induction of inflammation by macrophage-derived cytokines, utilization based on anti-inflammatory activity seems in contrast with its use as immunostimulant. The inhibitory effects of 80% ethanol extracts and subfractions obtained by petroleum ether, diethylether, ethylacetate and n-butanol from three Turkish subspecies of V. album L. (ssp. album, ssp. abietis, ssp. austriacum) against interleukins (IL-1alpha and IL-1beta) and tumor necrosis factor-alpha were studied. Ethanolic (80%) extracts of all three subspecies exhibited almost no significant inhibitory activity on the proinflammatory cytokines, at least in the concentrations applied in this study. In contrast, they induce a concentration dependent stimulation of these cytokines. On the other hand, moderate to weak, dose dependent inhibitory effects were observed on fractionation, which may be attributed to the existence of less polar components with anti-inflammatory activity. Based on our results, it was concluded that the utilization of ethanol extracts for anti-inflammatory purposes would not be beneficial probably due to the partial extraction of the low-molecular-weight polypeptides, i.e. viscotoxins, which induce an inflammatory response. Moreover, for anti-inflammatory effects, extracts of Viscum album ssp. austriacum may be preferred, since higher inhibitory ratios were obtained against inflammatory cytokines than with the other two subspecies.

キーワード 推奨
  1. (英) Interleukin-1α
  2. (英) Interleukin-1β
  3. (英) Loranthaceae
  4. (英) Mistletoe
  5. (英) Tumor necrosis factor-α
  6. (英) Viscum album ssp. abietis
  7. (英) Viscum album ssp.album
  8. (英) Viscum album ssp. austriacum
発行所 推奨 (英) Elsevier Science Ireland Ltd.
誌名 必須 Journal of Ethnopharmacology([Elsevier Science])
(pISSN: 0378-8741, eISSN: 1872-7573)
ISSN 任意 0378-8741
ISSN: 0378-8741 (pISSN: 0378-8741, eISSN: 1872-7573)
Title: Journal of ethnopharmacology
Title(ISO): J Ethnopharmacol
Publisher: Elsevier Ireland Ltd
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 61
必須 3
必須 195 200
都市 任意
年月日 必須 1998年 7月 初日
URL 任意 http://dx.doi.org/10.1016/S0378-8741(98)00038-5
DOI 任意 10.1016/S0378-8741(98)00038-5    (→Scopusで検索)
PMID 任意 9705010    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article