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著作: Morohoshi Kaori/[山本 裕史]/Kamata Ryo/Shiraishi Fujio/Koda Tomoko/Morita Masatoshi/Estrogenic activity of 37 components of commercial sunscreen lotions evaluated by in vitro assays,/[Toxicology In Vitro]

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EID
123787
EOID
880131
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LastModified
2017年12月19日(火) 16:06:48
Operator
三木 ちひろ
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TRUE
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Owner
[学科長]/[徳島大学.総合科学部.社会創生学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Morohoshi Kaori
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 山本 裕史
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Kamata Ryo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Shiraishi Fujio
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Koda Tomoko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Morita Masatoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Estrogenic activity of 37 components of commercial sunscreen lotions evaluated by in vitro assays,

副題 任意
要約 任意

(英) Thirty-seven chemical components of commercial sunscreen lotions were evaluated for estrogen agonistic and/or antagonistic activity using two in vitro assays, (1) an ELISA-based estrogen receptor competitive binding assay (ER-ELISA) and (2) a modified yeast two-hybrid estrogen assay, with and without addition of a rat liver preparation, S9 mix. Eleven compounds, most of which were benzophenone derivatives and parabens, showed binding affinity to ER by ER-ELISA without S9 mix. Although the activities of almost all of the compounds were attenuated by addition of S9 mix, 4-octylphenylsalicylate and 2,2'-dihydroxy-4,4'-dimethoxybenzophenone acquired estrogenic activity, suggesting metabolic activation of these compounds. Two benzophenones showed agonistic activity in the yeast two-hybrid assay without S9 mix. The activity of one of these was reduced by S9 treatment and a further two benzophenones was activated. Eight parabens were active in this assay without S9 exposure, but their activities were eliminated by S9 treatment. Benzophenones with para-phenolic hydroxyl groups and parabens with branched and/or longer linear chains were generally more potent in both bioassays. In addition, weak antagonistic activity of 4-t-butylphenyl-salicylate, 2-ethylhexyl 4-dimethylaminobenzoate and (+/-)-alpha-tocopherolacetate was observed with S9 treatment. In vivo testing of the compounds reported here to have estrogen agonistic and antagonistic activities is required to confirm their effects at an organismal level.

キーワード 推奨
  1. (英) Animals
  2. (英) Antioxidants
  3. (英) Benzoates
  4. (英) Benzophenones
  5. (英) Enzyme-Linked Immunosorbent Assay
  6. (英) Estrogen Antagonists
  7. (英) Estrogen Receptor alpha
  8. (英) Estrogens, Non-Steroidal
  9. (英) Liver
  10. (英) Parabens
  11. (英) Preservatives, Pharmaceutical
  12. (英) Rats
  13. (英) Saccharomyces cerevisiae
  14. (英) Salicylates
  15. (英) Subcellular Fractions
  16. (英) Sunscreening Agents
  17. (英) Triazoles
  18. (英) Ultraviolet Rays
発行所 推奨
誌名 必須 Toxicology In Vitro([Pergamon Press])
(pISSN: 0887-2333, eISSN: 1879-3177)
ISSN 任意 0887-2333
ISSN: 0887-2333 (pISSN: 0887-2333, eISSN: 1879-3177)
Title: Toxicology in vitro : an international journal published in association with BIBRA
Title(ISO): Toxicol In Vitro
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 19
必須 4
必須 457 469
都市 任意
年月日 必須 2005年 4月 初日
URL 任意
DOI 任意 10.1016/j.tiv.2005.01.004    (→Scopusで検索)
PMID 任意 15826804    (→Scopusで検索)
NAID 任意
WOS 任意 000228768500003
Scopus 任意 2-s2.0-17044374284
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: National Institute for Environmental Studies, Endocrine Disruptors and Dioxin Research Project, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: In Vitro

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article