徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座(2004年4月1日〜2015年3月31日)

1. 津村 恵子

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2. 李 雪飛

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3. (英) Murdiastuti Kwartarini

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4. (英) Parvin Nahid Most

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5. 赤松 徹也([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])

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6. 姚 陳娟([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生理学])

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7. 金森 憲雄

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8. (英) Inenaga, Kiyotoshi / (日) 稲永, 清敏 / (読) いねなが きよとし

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9. (英) Yamashita, Hiroshi / (日) 山下, 博 / (読) やました ひろし

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10. 細井 和雄

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(英) Downregulation of AQP2 expression in the kidney of polydipsic STR/N mice

(英) Aquaporin-2 (AQP2) is responsible for the concentration of urine in the kidney collecting tubule under the regulation of vasopressin. The mRNA level of this water channel in polydipsic STR/N mice was extremely reduced compared with that in normal ICR mice. In male mice, reduction of the AQP2 mRNA level was not evident at 3 wk of age, at which time water intake was not increased. At 10 wk of age, however, the AQP2 mRNA level was reduced to 10% of that in control mice, whereas water intake was increased by 36%. At 44 wk, the water intake became five times that of the control ICR mice, and the AQP2 mRNA level in these polydipsic mice was only approximately 5% of control. Similar changes were observed in the AQP2 protein level, suggesting that the mRNA level of AQP2 reflects the protein level of AQP2. These inverse changes in the AQP2 mRNA level and water intake were also evident in female mice. The data imply that polydipsia in STR/N mice may have affected AQP2 mRNA transcription in the kidney, resulting in reduced AQP2 expression, which would contribute to a reduction in overretention of water.

1. (英) Age Factors
2. (英) Animals
3. (英) Aquaporin 2
4. (英) Aquaporins
5. (英) Body Weight
6. (英) Diuresis
7. (英) Down-Regulation
8. (英) Drinking Behavior
9. (英) Female
10. (英) Kidney
11. (英) Male
12. (英) Mice
13. (英) Mice, Inbred ICR
14. (英) Mice, Inbred Strains
15. (英) Osmolar Concentration
16. (英) Polyuria
17. (英) RNA, Messenger
18. (英) Reverse Transcriptase Polymerase Chain Reaction
19. (英) Thirst

1. (英) Article.Affiliation: Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima 770-8504, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't